子宫内膜异位症女性血清中纤维母细胞生长因子-2水平升高。
Elevated levels of fibroblast growth factor-2 in serum from women with endometriosis.
作者信息
Bourlev Vladimir, Larsson Anders, Olovsson Matts
机构信息
Research Centre of Obstetrics, Gynaecology and Perinatology, Russian Academy of the Medical Sciences, Moscow, Russia.
出版信息
Am J Obstet Gynecol. 2006 Mar;194(3):755-9. doi: 10.1016/j.ajog.2005.08.064.
OBJECTIVE
The purpose of this study was to determine whether serum and peritoneal fluid levels of fibroblast growth factor-2 (FGF-2) differ between women with and without endometriosis and to examine the relationship between proliferative activity in the endometriotic lesions and the levels of FGF-2 in serum and peritoneal fluid.
STUDY DESIGN
Biopsy specimens of peritoneal endometriotic lesions (n = 25) were analyzed immunohistochemically regarding proliferative activity in stroma, glands, and blood vessels. The FGF-2 concentration was measured in peritoneal fluid and serum from 25 women with endometriosis and 14 healthy controls.
RESULTS
Patients with endometriosis had higher serum concentrations of FGF-2 during both the proliferative and secretory menstrual phases than healthy women. Peritoneal fluid levels of FGF-2 differed significantly between women with high and low proliferative activity in their endometriotic lesions.
CONCLUSION
Women with endometriosis have a higher serum level of FGF-2 than healthy controls.
目的
本研究旨在确定患有和未患有子宫内膜异位症的女性之间，血清和成纤维细胞生长因子-2（FGF-2）的腹腔液水平是否存在差异，并研究子宫内膜异位症病变中的增殖活性与血清和腹腔液中FGF-2水平之间的关系。
研究设计
对25例腹膜子宫内膜异位症病变的活检标本进行免疫组织化学分析，观察其基质、腺体和血管中的增殖活性。测量了25例患有子宫内膜异位症的女性和14例健康对照者的腹腔液和血清中FGF-2的浓度。
结果
在增殖期和分泌期，患有子宫内膜异位症的患者血清FGF-2浓度均高于健康女性。子宫内膜异位症病变增殖活性高和低的女性之间，腹腔液中FGF-2水平存在显著差异。
结论
患有子宫内膜异位症的女性血清FGF-2水平高于健康对照者。
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