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Involvement of vascular endothelial growth factor -460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis.血管内皮生长因子-460 C/T、+405 G/C和+936 C/T基因多态性与子宫内膜异位症发生的相关性
Biomed Rep. 2015 Mar;3(2):220-224. doi: 10.3892/br.2014.409. Epub 2014 Dec 19.
2
Vascular endothelial growth factor (-460 C/T, +405 G/C, and +936 C/T) polymorphisms and endometriosis risk in Tunisian population.突尼斯人群中血管内皮生长因子（-460 C/T、+405 G/C和+936 C/T）基因多态性与子宫内膜异位症风险
Syst Biol Reprod Med. 2015;61(4):238-44. doi: 10.3109/19396368.2015.1041622. Epub 2015 May 18.
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Noninvasive biomarkers of endometriosis: myth or reality?子宫内膜异位症的非侵入性生物标志物：神话还是现实？
Expert Rev Mol Diagn. 2014 Apr;14(3):365-85. doi: 10.1586/14737159.2014.899905.
4
Serum and peritoneal fluid levels of vascular endothelial growth factor in women with endometriosis.子宫内膜异位症女性血清和腹腔液中血管内皮生长因子的水平
Int J Fertil Steril. 2013 Jul;7(2):96-9. Epub 2013 Jul 31.
5
Soluble c-Met expression in the peritoneal fluid and serum of patients with different stages of endometriosis.不同阶段子宫内膜异位症患者腹腔液和血清中可溶性c-Met的表达
Arch Gynecol Obstet. 2014 May;289(5):1107-12. doi: 10.1007/s00404-013-3082-7. Epub 2013 Nov 12.
6
Vascular endothelial growth factor gene polymorphisms contribute to the risk of endometriosis: an updated systematic review and meta-analysis of 14 case-control studies.血管内皮生长因子基因多态性与子宫内膜异位症风险相关：对14项病例对照研究的最新系统评价和荟萃分析
Genet Mol Res. 2013 Apr 2;12(2):1035-44. doi: 10.4238/2013.April.2.20.
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Stem cell theory for the pathogenesis of endometriosis.子宫内膜异位症发病机制的干细胞理论。
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Increased plasma levels of phthalate esters in women with advanced-stage endometriosis: a prospective case-control study.在晚期子宫内膜异位症女性中，邻苯二甲酸酯类物质的血浆水平升高：一项前瞻性病例对照研究。
Fertil Steril. 2011 Jan;95(1):357-9. doi: 10.1016/j.fertnstert.2010.07.1059. Epub 2010 Aug 25.
9
Peripheral biomarkers of endometriosis: a systematic review.子宫内膜异位症的外周生物标志物：系统评价。
Hum Reprod Update. 2010 Nov-Dec;16(6):651-74. doi: 10.1093/humupd/dmq009. Epub 2010 May 12.
10
Metastatic or Embolic Endometriosis, due to the Menstrual Dissemination of Endometrial Tissue into the Venous Circulation.转移性或栓塞性子宫内膜异位症，由子宫内膜组织经月经播散至静脉循环所致。
Am J Pathol. 1927 Mar;3(2):93-110.43.

晚期子宫内膜异位症女性的血管内皮生长因子血清水平

VASCULAR ENDOTHELIAL GROWTH FACTOR SERUM LEVELS IN WOMEN WITH ADVANCED ENDOMETRIOSIS.

作者信息

Malutan A, Drugan T, Georgescu C, Ciortea R, Bucuri C, Bobric A, Rada M P, Mihu D

机构信息

"Iuliu Hatieganu" University of Medicine and Pharmacy, II Obstetrics and Gynecology Department, Cluj-Napoca, Romania.

"Iuliu Hatieganu" University of Medicine and Pharmacy, Dept. of Medical Informatics and Biostatistics, Cluj-Napoca, Romania.

出版信息

Acta Endocrinol (Buchar). 2016 Jan-Mar;12(1):7-13. doi: 10.4183/aeb.2016.7.

DOI:10.4183/aeb.2016.7
PMID:31258793
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6586760/
Abstract

CONTEXT

Endometriosis is a common gynecological disease, characterized by ectopic deposits of endometrial tissue outside of the uterine cavity, and it is associated with pelvic pain and infertility, with an important impact on the quality of life. At this point there is a controversy regarding the etiology and pathophysiology of endometriosis and it seems that pro-angiogenic growth factors might be involved, but their role is not completely understood.

OBJECTIVE

To evaluate the serum concentration of the main growth factors in patients with diagnosed endometriosis compared to healthy controls.

SUBJECTS AND METHODS

A total of 157 women were divided into two study groups (Group I - endometriosis; Group 2 - healthy women). Serum levels of VEGF, G-CSF, GM-CSF, b-FGF, EGF, and HGF were measured with Human Multiplex Cytokine Panels.

RESULTS

VEGF serum levels were significantly lower in women with endometriosis compared to controls (1.924±0.145 compared to 1.806±0.078 pg/mL, p<0.001). Serum levels of GM-CSF, b-FGF, EGF, and HGF respectively did not differ significantly between patients with endometriosis and healthy controls. G-CSF had a very low detection rate.

CONCLUSIONS

The present study showed that VEGF serum levels are significantly lower in endometriosis patients compared to healthy controls, indicating a possible role in endometriosis pathogenesis.

摘要

背景

子宫内膜异位症是一种常见的妇科疾病，其特征是子宫内膜组织在子宫腔外异位沉积，与盆腔疼痛和不孕相关，对生活质量有重要影响。目前关于子宫内膜异位症的病因和病理生理学存在争议，促血管生成生长因子似乎与之有关，但其作用尚未完全明确。

目的

评估确诊为子宫内膜异位症的患者与健康对照者体内主要生长因子的血清浓度。

对象与方法

共157名女性被分为两个研究组（第一组——子宫内膜异位症患者；第二组——健康女性）。采用人细胞因子多指标检测试剂盒检测血清中血管内皮生长因子（VEGF）、粒细胞集落刺激因子（G-CSF）、粒细胞-巨噬细胞集落刺激因子（GM-CSF）、碱性成纤维细胞生长因子（b-FGF）、表皮生长因子（EGF）和肝细胞生长因子（HGF）的水平。

结果

与对照组相比，子宫内膜异位症患者的VEGF血清水平显著降低（分别为1.924±0.145与1.806±0.078 pg/mL，p<0.001）。子宫内膜异位症患者与健康对照者的GM-CSF、b-FGF、EGF和HGF血清水平分别无显著差异。G-CSF的检出率很低。

结论

本研究表明，与健康对照者相比，子宫内膜异位症患者的VEGF血清水平显著降低，提示其在子宫内膜异位症发病机制中可能发挥作用。