Besbas Nesrin, Bayrakci Umut Selda, Kale Gulsev, Cengiz Ali Bulent, Akcoren Zuhal, Akinci Devrim, Kilic Ilke, Bakkaloglu Aysin
Department of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Pediatr Nephrol. 2006 May;21(5):740-2. doi: 10.1007/s00467-006-0051-4. Epub 2006 Mar 8.
This case report describes congenital nephrotic syndrome in a 2-month-old girl associated with cytomegalovirus infection. Histological examination on renal biopsy showed diffuse mesangial sclerosis and cytomegalic inclusion bodies in the tubular cells and in some glomeruli. Cytomegalovirus (CMV) polymerase chain reaction (PCR) titer in serum was high. Remission of pulmonary and renal symptoms was achieved with ganciclovir in 3 weeks. No recurrence of proteinuria was observed during the follow-up period of 14 months. These finding suggested a causal relationship between congenital nephrotic syndrome and cytomegalovirus infection.
本病例报告描述了一名2个月大女童的先天性肾病综合征，其与巨细胞病毒感染相关。肾活检的组织学检查显示弥漫性系膜硬化，肾小管细胞和一些肾小球中有巨细胞包涵体。血清中巨细胞病毒（CMV）聚合酶链反应（PCR）滴度较高。更昔洛韦治疗3周后，肺部和肾脏症状缓解。在14个月的随访期内未观察到蛋白尿复发。这些发现提示先天性肾病综合征与巨细胞病毒感染之间存在因果关系。
