Division of Paediatric Nephrology, Department of Paediatrics, Lady Hardinge Medical College and Associated Kalawati Saran Children Hospital, New Delhi, India.
CSIR Institute of Genomics and Integrative Biology, Delhi, India.
Paediatr Int Child Health. 2021 May;41(2):162-165. doi: 10.1080/20469047.2020.1823176. Epub 2020 Sep 29.
Infantile nephrotic syndrome is a rare disorder which is frequently caused by genetic defects. A 7-month-old girl presented with fever, loose stools and anasarca and was diagnosed with nephrotic syndrome. Work-up for a genetic cause was negative. Cytomegalovirus polymerase chain reaction (CMV PCR) was positive and the infant was treated with ganciclovir for 6 weeks, followed by valganciclovir for 10 weeks. All symptoms resolved within 2 weeks of commencing treatment and she attained complete remission within 4 weeks. CMV PCR was negative within 4 weeks of antiviral therapy. At 18 months follow-up she remained well. Appropriate treatment of infantile nephrotic syndrome secondary to CMV should result in recovery.
婴儿肾病综合征是一种罕见的疾病，常由遗传缺陷引起。一名 7 个月大的女孩因发热、腹泻和全身水肿就诊，被诊断为肾病综合征。遗传原因检查结果为阴性。巨细胞病毒聚合酶链反应（CMV-PCR）阳性，婴儿接受更昔洛韦治疗 6 周，随后接受缬更昔洛韦治疗 10 周。治疗开始后 2 周内所有症状均得到缓解，4 周内达到完全缓解。抗病毒治疗 4 周内 CMV-PCR 转为阴性。18 个月随访时，患儿情况良好。巨细胞病毒引起的婴儿肾病综合征的适当治疗应可使其康复。
