双锥酰胺A对一种非小细胞支气管癌细胞系的作用。
Effects of bistramide A on a non-small-cell bronchial carcinoma line.
作者信息
Roussakis C, Robillard N, Riou D, Biard J F, Pradal G, Piloquet P, Debitus C, Verbist J F
机构信息
Groupe de recherche Substances marines à Activité Biologique (SMAB), Faculté de Pharmacie, Nantes, France.
出版信息
Cancer Chemother Pharmacol. 1991;28(4):283-92. doi: 10.1007/BF00685536.
The antiproliferative effects of bistramide A, a nitrogenous dilactam polyether from Lissoclinum bistratum Sluiter (Urochordata), were studied at the level of the cell cycle in asynchronous cells of the NSCLCN6-L16 line. Bistramide A has a dual mechanism that induces blockade in the G1 phase (compatible with differentiation properties reported elsewhere) and causes polyploidy that is suggestive of inaptitude for cytokinesis. These effects confirm the results of cytomorphology studies in electron microscopy.
对来自皮海鞘（尾索动物）的含氮双内酰胺聚醚——双溴酰胺A，在NSCLCN6-L16系非同步细胞的细胞周期水平上研究了其抗增殖作用。双溴酰胺A具有双重机制，可诱导G1期阻滞（与其他地方报道的分化特性相符）并导致多倍体形成，这表明细胞不能进行胞质分裂。这些效应证实了电子显微镜下细胞形态学研究的结果。
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