Riou D, Roussakis C, Robillard N, Biard J F, Verbist J F
Groupe de recherche 'Substances marines à Activité Biologique' (SMAB), Faculté de Pharmacie, Nantes, France.
Biol Cell. 1993;77(3):261-4. doi: 10.1016/s0248-4900(05)80196-0.
Bistramide A, a new toxin isolated from a New Caledonian Urochordata, shows an antiproliferative effect on a non-small-cell lung carcinoma line in vitro and G1-blockade. In this work, the growth arrest induced by bistramide A was shown to be irreversible as assessed by growth kinetics of pretreated cells. Furthermore, the drug caused an underexpression of the nuclear antigen Ki67. These events are similar to a G1-differentiation cell cycle step blockage and a terminal maturation induction.
双溴马得菌素A是从新喀里多尼亚尾索动物中分离出的一种新毒素，在体外对非小细胞肺癌细胞系具有抗增殖作用并能诱导G1期阻滞。在这项研究中，通过预处理细胞的生长动力学评估发现，双溴马得菌素A诱导的生长停滞是不可逆的。此外，该药物导致核抗原Ki67表达不足。这些现象类似于G1期分化细胞周期步骤的阻滞和终末成熟的诱导。
