血清素转运体基因启动子区域多态性与中风后重度抑郁症相关。
Serotonin transporter gene promoter region polymorphism associated with poststroke major depression.
作者信息
Ramasubbu Rajamannar, Tobias Rose, Buchan Alastair M, Bech-Hansen N Torben
机构信息
Department of Psychiatry and Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada, T2N 2T9.
出版信息
J Neuropsychiatry Clin Neurosci. 2006 Winter;18(1):96-9. doi: 10.1176/jnp.18.1.96.
PMID:16525076
Abstract
The authors examined variations of serotonin transporter-linked promoter region (5-HTTLPR) functional polymorphism in 26 stroke patients with major depression and in 25 unrelated nondepressed stroke subjects of Caucasian descent. Findings indicate a significant association between 5-HTTLPR short variant genotype and poststroke major depression.
摘要
作者检测了26例患有重度抑郁症的中风患者以及25例无关的高加索裔非抑郁症中风患者的5-羟色胺转运体相关启动子区域（5-HTTLPR）功能多态性的变异情况。研究结果表明，5-HTTLPR短变异基因型与中风后重度抑郁症之间存在显著关联。
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