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5-羟色胺转运体基因启动子区多态性与卒中后抑郁的荟萃分析

Meta-analysis of 5-hydroxytryptamine transporter gene promoter region polymorphism and post-stroke depression.

机构信息

Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.

出版信息

J Int Med Res. 2020 Jun;48(6):300060520925943. doi: 10.1177/0300060520925943.

DOI:10.1177/0300060520925943
PMID:32495670
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7273569/
Abstract

OBJECTIVE

To investigate the relationship between 5-hydroxytryptamine transporter gene promoter region () gene polymorphism and post-stroke depression (PSD).

METHODS

We searched the CNKI, China Science and Technology Journal, China WanFang, PubMed, Embase, and Web of Science databases for studies of the relationship between polymorphism and PSD. Data were evaluated using Stata software.

RESULTS

The L allele was significantly related to the S allele (OR = 0.57, 95% confidence interval (CI) 0.49-0.65). The dominant genotype LL + LS was related to SS (OR = 0.48, 95%CI 0.39-0.59), the recessive genotype LL was related to LS + SS (OR = 0.39, 95%CI: 0.30-0.51), the homozygous genotype LL was related to SS (OR = 0.24, 95%CI 0.18-0.33), and the heterozygous genotype LS was related to SS (OR = 0.55, 95 CI 0.44-0.68). All the differences were significant. Ethnicity subgroup analysis showed significant differences among the five genotypes in both Asians and Caucasians. Hardy-Weinberg equilibrium (HWE) subgroup analysis showed that, after removal of a non-HWE-conforming control group, all five genotypes were significant and genotypes LL, LS + LL, and LS and L allele had beneficial effects on recovery from PSD.

CONCLUSION

gene polymorphism is strongly associated with PSD, and the LL, LS + LL, and LS genotypes and L allele may protect against this condition.

摘要

目的

探讨 5-羟色胺转运体基因启动子区（）基因多态性与卒中后抑郁（PSD）的关系。

方法

计算机检索中国知网、中国科技期刊全文数据库、万方数据库、PubMed、Embase 和 Web of Science 数据库，查找关于基因多态性与 PSD 关系的研究，采用 Stata 软件进行数据分析。

结果

L 等位基因与 S 等位基因显著相关（OR=0.57，95%CI 0.49-0.65）。优势基因型 LL+LS 与 SS 相关（OR=0.48，95%CI 0.39-0.59），隐性基因型 LL 与 LS+SS 相关（OR=0.39，95%CI：0.30-0.51），纯合基因型 LL 与 SS 相关（OR=0.24，95%CI 0.18-0.33），杂合基因型 LS 与 SS 相关（OR=0.55，95%CI 0.44-0.68）。所有差异均有统计学意义。亚组分析显示，在亚洲人和白种人中，5 种基因型的差异均有统计学意义。Hardy-Weinberg 平衡（HWE）亚组分析显示，剔除非 HWE 对照组后，所有 5 种基因型均有统计学意义，且 LL、LS+LL 和 LS 基因型及 L 等位基因对 PSD 的恢复有保护作用。

结论

基因多态性与 PSD 密切相关，LL、LS+LL 和 LS 基因型及 L 等位基因可能对 PSD 有保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee7d/7273569/723105659b59/10.1177_0300060520925943-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee7d/7273569/003000750446/10.1177_0300060520925943-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee7d/7273569/83518031e414/10.1177_0300060520925943-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee7d/7273569/81885e250918/10.1177_0300060520925943-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee7d/7273569/723105659b59/10.1177_0300060520925943-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee7d/7273569/003000750446/10.1177_0300060520925943-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee7d/7273569/83518031e414/10.1177_0300060520925943-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee7d/7273569/81885e250918/10.1177_0300060520925943-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee7d/7273569/723105659b59/10.1177_0300060520925943-fig4.jpg

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