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Synthesis and anti-bacterial activity of some novel 2-(6-fluorochroman-2-yl)-1-alkyl/acyl/aroyl-1H-benzimidazoles.

作者信息

Kumar Bobba Venkata Siva, Vaidya Sanjay Dashrath, Kumar Ramanatham Vinod, Bhirud Shekar Bhaskar, Mane Ramchandra Bhimrao

机构信息

Glenmark Research Center, Plot No. A-607, T.T.C. Industrial Area, M.I.D.C. Mahape Navi Mumbai 400 709, India.

出版信息

Eur J Med Chem. 2006 May;41(5):599-604. doi: 10.1016/j.ejmech.2006.01.006. Epub 2006 Mar 9.

DOI:10.1016/j.ejmech.2006.01.006
PMID:16527375
Abstract

Synthesis of some novel 2-(6-fluorochroman-2-yl)-1-alkyl/acyl/aroyl-1H-benzimidazoles by the condensation of o-phenylenediamine with 6-fluoro-3,4-dihydro-2H-chroman-2-carboxylic acid, and subsequent reactions with different types of electrophiles, have been reported. Some compounds exhibited promising anti-bacterial activity against Salmonella typhimurium; however, they showed poor activity against S. aureus. The biological activity against PDE IV for potential anti-asthamatic effect, and against DP-IV and PTP 1B for potential anti-diabetic effects was disappointing.

摘要

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