Holmes P V, Bergström S
J Reprod Fertil. 1975 May;43(2):329-32. doi: 10.1530/jrf.0.0430329.
Oestrogen administration to female mice with 'delayed' implantation induces changes in the uterus and blastocysts followed by implantation and normal gestation. The second messenger for oestrogen, adenosine 3' :5'-cyclic monophosphate (cAMP), was instilled into the uterine lumen of females with 'delayed implanting' blastocysts to determinewhether it also is able to induce implantation. Implantation of the blastocysts was induced by cAMP but the pregnancies were not maintained to tem. These results are discussed with respect to the changes in blastocysts induced by cAMP and with respect to the reported contraceptive effects of cAMP in normal mice.
给具有“延迟”着床的雌性小鼠施用雌激素会引起子宫和胚泡的变化，随后着床并正常妊娠。将雌激素的第二信使3':5'-环磷酸腺苷（cAMP）注入具有“延迟着床”胚泡的雌性小鼠的子宫腔中，以确定它是否也能够诱导着床。cAMP诱导了胚泡的着床，但妊娠未能维持到足月。结合cAMP诱导的胚泡变化以及报道的cAMP对正常小鼠的避孕作用对这些结果进行了讨论。
