Webb F T
J Reprod Fertil. 1977 May;50(1):83-9. doi: 10.1530/jrf.0.0500083.
Experiments are described that demonstrate the ability of dibutyryl cyclic AMP (dcAMP) to induced oestrogen-like changes in the uteri of ovariectomized mice treated with progesterone. A single intraluminal injection of 6-14 micrograms dcAMP in 0-02 ml phosphate-buffered saline promoted cell division in the uterine stroma and sensitized the endometrium so that a decidual reaction could be induced by a subsequent injection of arachis oil into the uterine lumen. Since dcAMP has already been shown to induce implantation of diapausing mouse blastocysts in the absence of oestrogen, it is suggested that cyclic AMP is involved in egg implantation in rodents.
本文描述了一些实验，这些实验证明了二丁酰环磷腺苷（dcAMP）能够在接受孕酮治疗的去卵巢小鼠子宫中诱导出类似雌激素的变化。在0.02毫升磷酸盐缓冲盐水中单次腔内注射6 - 14微克dcAMP，可促进子宫基质中的细胞分裂，并使子宫内膜敏感化，从而通过随后向子宫腔内注射花生油诱导蜕膜反应。由于已经证明dcAMP在没有雌激素的情况下能诱导滞育小鼠囊胚着床，因此有人提出环磷腺苷参与啮齿动物的卵子着床过程。
