某些硫代氨基甲酸盐化合物对乙醛脱氢酶的影响及其与双硫仑-乙醇反应的关系
Effect of some thiocarbamate compounds on aldehyde dehydrogenase and implications for the disulfiram ethanol reaction.
作者信息
Kitson T M
机构信息
Department of Chemistry and Biochemistry, Massey University, Palmerston North, New Zealand.
出版信息
Biochem J. 1991 Aug 15;278 ( Pt 1)(Pt 1):189-92. doi: 10.1042/bj2780189.
Abstract
The effects of S-methyl diethyldithiocarbamate, S-methyl diethylmonothiocarbamate and bis(diethylcarbamoyl) disulphide on sheep liver cytoplasmic aldehyde dehydrogenase were investigated in vitro. The first compound has negligible effect. The second one is a weak inhibitor of the esterase activity of the enzyme and a weaker inhibitor of the dehydrogenase activity. A very low concentration of the third compound, however, acts as a potent inactivator of aldehyde dehydrogenase, similar in this respect to disulfiram, although somewhat slower to react. The possible involvement of these compounds in the physiological phenomenon known as the disulfiram ethanol reaction is discussed.
摘要
体外研究了S-甲基二乙基二硫代氨基甲酸盐、S-甲基二乙基单硫代氨基甲酸盐和双（二乙基氨基甲酰基）二硫化物对绵羊肝脏细胞质醛脱氢酶的影响。第一种化合物的影响可忽略不计。第二种是该酶酯酶活性的弱抑制剂，对脱氢酶活性的抑制作用较弱。然而，第三种化合物的极低浓度可作为醛脱氢酶的有效失活剂，在这方面与双硫仑相似，尽管反应稍慢。讨论了这些化合物可能参与被称为双硫仑-乙醇反应的生理现象。
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