高浓度的醛类物质会减缓细胞质醛脱氢酶与硫醇基团修饰剂的反应。
High concentrations of aldehydes slow the reaction of cytoplasmic aldehyde dehydrogenase with thiol-group modifiers.
作者信息
Kitson T M
出版信息
Biochem J. 1985 Jun 15;228(3):765-7. doi: 10.1042/bj2280765.
Abstract
High concentrations of aldehydes slow the inactivation of cytoplasmic aldehyde dehydrogenase by disulfiram and also slow the reaction of the enzyme with 2,2'-dithiodipyridine. It is concluded that a low-affinity aldehyde-binding site is probably the site at which thiol-group modifiers react with aldehyde dehydrogenase, as well as being the active site for hydrolysis of 4-nitrophenyl acetate.
摘要
高浓度醛类会减缓双硫仑对细胞质醛脱氢酶的失活作用，同时也会减缓该酶与2,2'-二硫代二吡啶的反应。由此得出结论，低亲和力醛结合位点可能是硫醇基团修饰剂与醛脱氢酶发生反应的位点，也是乙酸对硝基苯酯水解的活性位点。
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