Carper W R, Dorey R C, Beber J H
Department of Psychiatry, Veteran's Administration Medical Center, Wichita, KS 67218.
Clin Chem. 1987 Oct;33(10):1906-8.
We investigated the effect of disulfiram (Antabuse) on the activity of alcohol dehydrogenase (EC 1.1.1.1) in vitro. We observed a time-dependent inhibition of this dehydrogenase by disulfiram and diethyldithiocarbamate similar to that obtained for aldehyde dehydrogenase (EC 1.2.1.3). These results suggest a possible explanation for various side effects observed in the clinical use of Antabuse.
我们在体外研究了双硫仑（戒酒硫）对乙醇脱氢酶（EC 1.1.1.1）活性的影响。我们观察到双硫仑和二乙基二硫代氨基甲酸盐对该脱氢酶具有时间依赖性抑制作用，这与醛脱氢酶（EC 1.2.1.3）的情况相似。这些结果为戒酒硫临床应用中观察到的各种副作用提供了一种可能的解释。
