用于牙周再生医学的基因治疗学
Gene therapeutics for periodontal regenerative medicine.
作者信息
Ramseier Christoph A, Abramson Zachary R, Jin Qiming, Giannobile William V
机构信息
Center for Craniofacial Regeneration and Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, MI 48106, USA.
出版信息
Dent Clin North Am. 2006 Apr;50(2):245-63, ix. doi: 10.1016/j.cden.2005.12.001.
There has been significant advancement in the field of periodontal tissue engineering over the past decade for the repair of tooth-supporting structures. Although encouraging results for periodontal tissue regeneration have been found in numerous clinical investigations using recombinant growth factors, limitations exist with topical protein delivery. Newer approaches seek to develop methodologies that optimize growth factor targeting to maximize the therapeutic outcome of periodontal regenerative procedures. Genetic approaches in periodontal tissue engineering show early progress in achieving delivery of growth factor genes, such as platelet-derived growth factor or bone morphogenetic protein, to periodontal lesions. Ongoing investigations in ex vivo and in vivo gene transfer to periodontia seek to examine the extent of the potential effects in stimulating periodontal tissue engineering.
在过去十年中，用于修复牙齿支持结构的牙周组织工程领域取得了显著进展。尽管在众多使用重组生长因子的临床研究中发现了牙周组织再生的令人鼓舞的结果，但局部蛋白质递送存在局限性。新的方法试图开发优化生长因子靶向的方法，以最大化牙周再生程序的治疗效果。牙周组织工程中的基因方法在将生长因子基因（如血小板衍生生长因子或骨形态发生蛋白）递送至牙周病变方面显示出早期进展。正在进行的关于牙周组织体外和体内基因转移的研究旨在研究刺激牙周组织工程的潜在影响程度。
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