Periodontol 2000. 2012 Jun;59(1):185-202. doi: 10.1111/j.1600-0757.2011.00432.x.
Reconstructive therapies to promote the regeneration of lost periodontal support have been investigated through both preclinical and clinical studies. Advanced regenerative technologies using new barrier-membrane techniques, cell-growth-stimulating proteins or gene-delivery applications have entered the clinical arena. Wound-healing approaches using growth factors to target the restoration of tooth-supporting bone, periodontal ligament and cementum are shown to significantly advance the field of periodontal-regenerative medicine. Topical delivery of growth factors, such as platelet-derived growth factor, fibroblast growth factor or bone morphogenetic proteins, to periodontal wounds has demonstrated promising results. Future directions in the delivery of growth factors or other signaling models involve the development of innovative scaffolding matrices, cell therapy and gene transfer, and these issues are discussed in this paper.
通过临床前和临床研究，已经探索了促进牙周支持组织再生的重建治疗方法。使用新型屏障膜技术、细胞生长刺激蛋白或基因传递应用的先进再生技术已经进入临床领域。使用生长因子的伤口愈合方法靶向牙支持骨、牙周韧带和牙骨质的修复，显著推动了牙周再生医学领域的发展。将生长因子（如血小板衍生生长因子、成纤维细胞生长因子或骨形态发生蛋白）局部递送至牙周伤口已显示出有前景的结果。生长因子或其他信号模型传递的未来方向涉及创新支架基质、细胞治疗和基因转移的发展，本文讨论了这些问题。
