Mohanka Manish, Irwin Melinda, Heckbert Susan R, Yasui Yutaka, Sorensen Bess, Chubak Jessica, Tworoger Shelley S, Ulrich Cornelia M, McTiernan Anne
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Med Sci Sports Exerc. 2006 Feb;38(2):231-9. doi: 10.1249/01.mss.0000184584.95000.e4.
This analysis was conducted to study the effect of a 1-yr moderate-intensity aerobic exercise program on serum lipoproteins among overweight/obese postmenopausal women.
We randomized 173 sedentary (VO2max = 20.2 mL.kg(-1).min(-1)), overweight/obese women (body mass index (BMI) 25.0-42.0 kg.m(-2) or body fat > 33% if BMI 24.0-25.0) aged 50-75 yr, not using hormone therapy, living in the Seattle area, to an exercise intervention or stretching control group. The exercise intervention included facility and home-based exercise (45 min, 5 d.wk(-1) of moderate-intensity sports or recreational exercise). Total cholesterol (TC), triglycerides, and high-density lipoprotein (HDL) were determined by chemical assay; low-density lipoprotein (LDL) was then calculated.
Of the 173 women, 170 (98.3%) completed the study with exercisers averaging 176 (SD 91) min.wk(-1) of moderate- to vigorous-intensity (60%-75% HRmax) exercise, expending approximately 3828 kJ.wk(-1) (SD 2053). Exercisers, compared with stretchers, significantly increased their VO2max (+11%, P<0.001) and lost more body weight (-1.4 kg, P < 0.05), DEXA-% total body fat (-1.0, P < 0.005), L4-5 computed tomography intraabdominal fat (-8.6 cm2, P < 0.05) and subcutaneous abdominal fat (-28.8 cm2, P < 0.005) after 12 months. Mean (SD) baseline lipoprotein levels for TC, LDL, HDL, and triglycerides were 231 (39), 152 (39), 52 (12), and 135 (65) mg.dL(-1), respectively. We observed no significant change in serum lipoprotein levels among exercisers compared with stretchers at either 3 or 12 months postrandomization. We did not observe a statistically significant effect of exercise on serum lipoproteins in subgroups that changed their intraabdominal and subcutaneous fat, percent total body fat, or VO2max the most, or that adhered to the exercise regimen the most over 1 yr.
It appears that a year long moderate-intensity exercise program alone does not significantly alter serum lipoprotein levels among overweight/obese postmenopausal women.
本分析旨在研究为期1年的中等强度有氧运动计划对超重/肥胖绝经后女性血清脂蛋白的影响。
我们将173名久坐不动（最大摄氧量=20.2 mL·kg⁻¹·min⁻¹）、超重/肥胖的女性（体重指数（BMI）为25.0 - 42.0 kg·m⁻²，若BMI为24.0 - 25.0，则体脂>33%），年龄在50 - 75岁，未使用激素疗法，居住在西雅图地区的女性，随机分为运动干预组或伸展对照组。运动干预包括在健身设施和家中进行的运动（45分钟，每周5天的中等强度体育或娱乐运动）。总胆固醇（TC）、甘油三酯和高密度脂蛋白（HDL）通过化学分析测定；然后计算低密度脂蛋白（LDL）。
173名女性中，170名（98.3%）完成了研究，运动组平均每周进行176（标准差91）分钟的中等至高强度（60% - 75%最大心率）运动，每周消耗约3828千焦（标准差2053）。与伸展组相比，运动组在12个月后显著提高了她们的最大摄氧量（+11%，P<0.001），体重减轻更多（-1.4千克，P < 0.05），双能X线吸收法测定的全身脂肪百分比（-1.0，P < 0.005），L4 - 5节段计算机断层扫描测定的腹部内脏脂肪（-8.6平方厘米，P < 0.05）和腹部皮下脂肪（-28.8平方厘米，P < 0.005）。TC、LDL、HDL和甘油三酯的平均（标准差）基线脂蛋白水平分别为231（39）、152（39）、52（12）和135（65）mg·dL⁻¹。随机分组后3个月和12个月时，与伸展组相比，我们未观察到运动组血清脂蛋白水平有显著变化。在腹部内脏和皮下脂肪、全身脂肪百分比或最大摄氧量变化最大的亚组中，或在1年中最坚持运动方案的亚组中，我们未观察到运动对血清脂蛋白有统计学显著影响。
看来仅为期一年的中等强度运动计划并不能显著改变超重/肥胖绝经后女性的血清脂蛋白水平。
