Ready A E, Drinkwater D T, Ducas J, Fitzpatrick D W, Brereton D G, Oades S C
Health, Leisure and Human Performance Research Institute, Faculty of Medicine, University of Manitoba, Winnipeg.
Can J Cardiol. 1995 Nov;11(10):905-12.
To examine the effect of a moderate exercise regimen on total serum cholesterol, triglyceride, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), body composition and cardiovascular fitness (VO2 max) in mildly hyperlipidemic women, postmenopause.
Randomized assignment to walking (n = 24) or control (n = 16) groups.
Community based intervention.
Over 300 volunteers were screened to obtain the sample of 40 eligible women. Participants were mildly hyperlipidemic, postmenopause (mean age 62.0 +/- 5.7 years), sedentary, nonsmokers and not on hormone replacement therapy. Results are reported for the 25 subjects (15 walkers, 10 controls) who completed the study.
Exercisers walked an average of 54.3 +/- 7.7 mins/day, 4.9 +/- 1.7 days/week, at an intensity of 54% maximum heart rate reserve, for six months. Participants were counselled not to change their diets.
Total serum cholesterol, triglyceride, total serum cholesterol: HDL-C ratio, weight and fat mass decreased significantly in the walkers compared with the controls (P < 0.05), as did body mass index (P < 0.01). Walking resulted in a significant increase in VO2 max (P < 0.01). Changes in serum lipids were significantly related to changes in body fat, but not to change in aerobic fitness. There were no changes in dietary intake.
A moderate intensity exercise program induces favourable alterations in total serum cholesterol and other atherogenic indices in hyperlipidemic women postmenopause, and these changes are related more to loss of body fat than to increased fitness level.
研究适度运动方案对轻度血脂异常的绝经后女性血清总胆固醇、甘油三酯、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、身体成分和心血管健康状况（最大摄氧量）的影响。
随机分为步行组（n = 24）和对照组（n = 16）。
基于社区的干预。
对300多名志愿者进行筛查，以获得40名符合条件的女性样本。参与者为轻度血脂异常的绝经后女性（平均年龄62.0±5.7岁），久坐不动，不吸烟，未接受激素替代疗法。报告了完成研究的25名受试者（15名步行者，10名对照组）的结果。
运动者平均每天步行54.3±7.7分钟, 每周4.9±1.7天，运动强度为最大心率储备的54%，持续六个月。建议参与者不要改变饮食。
与对照组相比，步行者的血清总胆固醇、甘油三酯、血清总胆固醇与HDL-C比值、体重和脂肪量显著降低（P < 0.05），体重指数也显著降低（P < 0.01）。步行使最大摄氧量显著增加（P < 0.01）。血脂变化与体脂变化显著相关，但与有氧适能变化无关。饮食摄入量没有变化。
适度强度的运动方案可使轻度血脂异常的绝经后女性血清总胆固醇和其他致动脉粥样硬化指标发生有益改变，这些变化更多地与体脂减少有关，而非与体能水平提高有关。
