Siti-Aishah M A, Isahak I, Sabil D, Sahlan F, Tahir H M, Yahya A A
Departments of Pathology.
Malays J Med Sci. 2000 Jul;7(2):27-31.
Human papillomavirus (HPV) is the commonest sexually transmitted viral infection and one of its manifestations is genital warts or condyloma acuminata. Eight cases of vulvo-vaginal warts were diagnosed between January 1992 and December 1993. There were 4 Malays, 2 Chinese and 2 Indians. The patients' age ranged from 22 to 43 years (mean 27.9 years). Formalin-fixed, paraffin-embedded tissues were studied by histology and in situ hybridization using biotinylated probes to detect the HPV deoxyribonucleic acid (DNA) of types 6, 11, 16, 18, 31 and 33. All vulvar and vaginal lesions showed typical histopathological features of condylomatous changes. HPV 6 and HPV 11 were detected in 100% (8/8) and 87.5% (7/8) of all cases, respectively. HPVs 16, 18, 31 and 33 were not found. The positive cells were mainly in the upper layers of the squamous epithelium. The hybridization data indicated that the HPV found in this study one of the same types as found in other studies.
人乳头瘤病毒（HPV）是最常见的性传播病毒感染，其表现之一是尖锐湿疣或生殖器疣。1992年1月至1993年12月期间诊断出8例外阴阴道疣病例。其中有4名马来人、2名中国人和2名印度人。患者年龄在22岁至43岁之间（平均27.9岁）。对福尔马林固定、石蜡包埋的组织进行了组织学研究，并使用生物素化探针进行原位杂交，以检测6、11、16、18、31和33型人乳头瘤病毒脱氧核糖核酸（DNA）。所有外阴和阴道病变均表现出典型的湿疣样改变的组织病理学特征。分别在所有病例的100%（8/8）和87.5%（7/8）中检测到HPV 6和HPV 11。未发现HPV 16、18、31和33。阳性细胞主要位于鳞状上皮的上层。杂交数据表明，本研究中发现的HPV与其他研究中发现的HPV属于同一类型。
