濒危红尾袋鼬（Phascogale calura）的免疫组织。
The immune tissues of the endangered red-tailed phascogale (Phascogale calura).
作者信息
Old J M, Carman R L, Fry G, Deane E M
机构信息
Department of Biological Sciences, Division of Environmental and Life Sciences, Macquarie University, New South Wales, Australia.
出版信息
J Anat. 2006 Mar;208(3):381-7. doi: 10.1111/j.1469-7580.2006.00530.x.
The lymphoid tissues of the red-tailed phascogale (Phascogale calura) were examined using histological and immunohistochemical techniques. The distribution of immune cells in the tissue beds was documented using antibodies to surface markers CD3 and an MHC Class II antigen (equivalent to HLA DRII). Spleen, gut-associated lymphoid tissues (GALT), lung, bronchus-associated lymphoid tissue (BALT) and liver were examined. The spleen had defined areas of red and white pulp, with follicles containing tingible-bodied macrophages. Anti-CD3 and anti-HLA DRII antibodies revealed the presence of T cells in areas of white pulp and around the peri-arterial lymphatic sheaths. GALT and BALT were detected and appeared as scattered areas of lymphocytes in the tissues beds. This is the first study to report on the lymphoid tissues of this endangered species of marsupial and the first report of the capacity of anti-human antibodies to a surface MHC molecule to react with Dasyurid cells.
采用组织学和免疫组织化学技术对红尾帚尾袋鼬（Phascogale calura）的淋巴组织进行了检查。使用针对表面标志物CD3和MHC II类抗原（等同于HLA DRII）的抗体记录了免疫细胞在组织床中的分布情况。对脾脏、肠道相关淋巴组织（GALT）、肺、支气管相关淋巴组织（BALT）和肝脏进行了检查。脾脏有明确的红髓和白髓区域，滤泡中含有可染体巨噬细胞。抗CD3和抗HLA DRII抗体显示在白髓区域和动脉周围淋巴鞘周围存在T细胞。检测到了GALT和BALT，它们在组织床中表现为淋巴细胞的散在区域。这是第一项关于这种濒危有袋类动物淋巴组织的研究报告，也是第一项关于抗人类表面MHC分子抗体与袋鼬科动物细胞发生反应能力的报告。
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