Rylander Marissa Nichole, Feng Yusheng, Bass Jon, Diller Kenneth R
Department of Biomedical Engineering, The University of Texas at Austin, 1 University Station, C0800, Austin, TX 78712-1084, USA.
Ann N Y Acad Sci. 2005 Dec;1066:222-42. doi: 10.1196/annals.1363.009.
Heat-shock proteins (HSPs) are critical components of a cell's defense mechanism against injury associated with adverse stresses. Initiating insults, such as elevated or depressed temperature, diminished oxygen, and pressure, increase HSP expression and can protect cells against subsequent, otherwise lethal, insults. Although HSPs are very beneficial to the normal cell, cancer cells can also use HSPs in response to stresses associated with various therapies (hyperthermia, chemotherapy, radiation), mitigating injury incurred by these treatments. Hyperthermia is a common treatment option for prostate cancer. HSPs can be induced in regions of the tumor where temperatures are insufficient to cause lethal thermal necrosis. Elevated HSP expression can enhance tumor cell viability and impart increased resistance to subsequent chemotherapy and radiation treatments, thereby promoting tumor recurrence. An understanding of the structure, function, and thermally stimulated HSP kinetics and cell injury for prostate cancer cells is essential to designing effective hyperthermia protocols. Measured thermally induced cellular HSP expression and injury data can be employed to develop a treatment planning model for optimization of the tissue response to therapy based on accurate prediction of the HSP expression and cell damage distribution.
热休克蛋白（HSPs）是细胞防御机制的关键组成部分，可抵御与不良应激相关的损伤。引发损伤的因素，如温度升高或降低、氧气减少和压力增加，会增加热休克蛋白的表达，并能保护细胞免受随后的、否则会致命的损伤。尽管热休克蛋白对正常细胞非常有益，但癌细胞也可利用热休克蛋白来应对与各种治疗（热疗、化疗、放疗）相关的应激，减轻这些治疗所导致的损伤。热疗是前列腺癌的一种常见治疗选择。在肿瘤中温度不足以引起致死性热坏死的区域可诱导热休克蛋白产生。热休克蛋白表达升高可增强肿瘤细胞的活力，并使其对随后的化疗和放疗产生更大的抗性，从而促进肿瘤复发。了解前列腺癌细胞的结构、功能、热刺激热休克蛋白动力学和细胞损伤，对于设计有效的热疗方案至关重要。测量得到的热诱导细胞热休克蛋白表达和损伤数据可用于建立一个治疗计划模型，以便基于对热休克蛋白表达和细胞损伤分布的准确预测来优化组织对治疗的反应。
