Shanghai University School of Medicine, Shanghai, PR China.
Department of Health Toxicology, Faculty of Naval Medicine, Second Military Medical University, Shanghai, PR China.
Histol Histopathol. 2024 Jul;39(7):845-851. doi: 10.14670/HH-18-693. Epub 2023 Dec 19.
Heat shock proteins (HSPs) are a family of proteins involved in protein folding and maturation that are expressed by cells in response to stressors including heat shock. Recent studies have demonstrated that HSPs play major roles in carcinogenesis by regulating angiogenesis, cell proliferation, migration, invasion, metastasis, apoptosis, as well as therapy resistance to certain anticancer drugs. Despite being the largest and most diverse subgroup of the HSP family, HSP40 (DNAJ) is an understudied family of co-chaperones. HSP40 family members are also known to be involved in various types of cancers. In this article, we review the involvement of human HSP40 family members in various aspects of cancer biology. In addition, we highlight the possible potential of HSP40 as a tumor biomarker or drug target for improving the prognosis and treatment of cancer patients in the future.
热休克蛋白（HSPs）是一组参与蛋白质折叠和成熟的蛋白质，细胞在受到热休克等应激源的刺激时会表达 HSPs。最近的研究表明，HSPs 通过调节血管生成、细胞增殖、迁移、侵袭、转移、凋亡以及对某些抗癌药物的治疗耐药性，在肿瘤发生中发挥重要作用。尽管 HSP40（DNAJ）是 HSP 家族中最大和最多样化的亚群，但它是一个研究不足的伴侣蛋白家族。HSP40 家族成员也被认为与各种类型的癌症有关。在本文中，我们综述了人类 HSP40 家族成员在癌症生物学各个方面的作用。此外，我们还强调了 HSP40 作为肿瘤生物标志物或药物靶点的可能潜力，以改善未来癌症患者的预后和治疗。
