Hafner A, Wanke R, Schmidt P, Hänichen T, Bise K
Institut für Tierpathologie, Ludwig-Maximilians-Universität München.
Tierarztl Prax. 1991 Jun;19(3):258-62.
Multiple malformations were shown in a bovine fetus delivered at slaughter after a gestation period of 469 days. Hypoplasia of the adenohypophysis and a bilateral agenesis of the adrenal cortex suggest that the failure of initiation of parturition resulted from a fetal deficiency of ACTH and glucocorticoid hormones. ACTH, GH (growth hormone) and prolactin could not be demonstrated immunohistochemically within the adenohypophysis. However, TSH immunoreactive pituitary cells were demonstrable. Nevertheless, considering the extremely reduced size of the adenohypophysis a fetal deficiency of TSH is suspected. This view is supported by a bilateral hypoplasia of the thyroid gland. Additionally, the complex fetal endocrine dysfunction had led to a growth retardation of the fetus.
一头妊娠期为469天、在屠宰时娩出的牛胎儿出现了多种畸形。腺垂体发育不全和双侧肾上腺皮质发育不全表明，分娩启动失败是由于胎儿促肾上腺皮质激素（ACTH）和糖皮质激素缺乏所致。在腺垂体内，无法通过免疫组织化学方法检测到ACTH、生长激素（GH）和催乳素。然而，可检测到促甲状腺激素（TSH）免疫反应性垂体细胞。尽管如此，考虑到腺垂体的尺寸极度缩小，怀疑胎儿存在TSH缺乏。甲状腺双侧发育不全支持了这一观点。此外，复杂的胎儿内分泌功能障碍导致了胎儿生长发育迟缓。
