Kim Tae-Suk, Pae Chi-Un, Yoon Su-Jung, Jang Woo-Young, Lee Nam Jin, Kim Jung-Jin, Lee Soo-Jung, Lee Chul, Paik In-Ho, Lee Chang-Uk
Department of Psychiatry, Kangnam St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Seoul, Korea.
Int J Geriatr Psychiatry. 2006 Apr;21(4):344-8. doi: 10.1002/gps.1469.
It has been suggested that oxidative injuries have an important role in the pathogenesis of Alzheimer's disease (AD). In this study, we assess whether the plasma levels of albumin, bilirubin, and uric acid would be altered in the AD patients compared to those of the healthy controls. Furthermore, we tried to find the correlations between plasma antioxidant levels and the cognitive function in AD patients.
The plasma albumin, bilirubin, and uric acid levels were measured by standard methods in 101 AD patients and 101 healthy controls. The Korean version of the Mini Mental Status Examination (MMSE-K) was used to evaluate the cognitive functions of AD patients.
A significant reduction in the albumin, bilirubin, and uric acid levels in the AD group was found compared to those of the control group. The scores of MMSE-K showed the positive correlation with albumin level in the AD group after adjusting confounding factors such as body mass index, gender and age.
This study showed that oxidative injuries could be involved in the pathogenesis of AD, as well as indicating that some antioxidant might be associated with the cognitive functions in AD.
有人提出氧化损伤在阿尔茨海默病（AD）的发病机制中起重要作用。在本研究中，我们评估与健康对照者相比，AD患者血浆中白蛋白、胆红素和尿酸水平是否会发生改变。此外，我们试图找出AD患者血浆抗氧化剂水平与认知功能之间的相关性。
采用标准方法测量101例AD患者和101例健康对照者的血浆白蛋白、胆红素和尿酸水平。使用韩国版简易精神状态检查表（MMSE-K）评估AD患者的认知功能。
与对照组相比，AD组的白蛋白、胆红素和尿酸水平显著降低。在调整体重指数、性别和年龄等混杂因素后，AD组MMSE-K评分与白蛋白水平呈正相关。
本研究表明氧化损伤可能参与AD的发病机制，同时也表明某些抗氧化剂可能与AD患者的认知功能有关。
