Gleeson P A, Toh B H
Department of Pathology and Immunology, Monash University Medical School, Prahran, Victoria, Australia.
Immunol Today. 1991 Jul;12(7):233-8. doi: 10.1016/0167-5699(91)90036-S.
Autoimmune gastritis, leading to pernicious anaemia, is an organ-specific autoimmune disease characterized by chronic atrophic gastritis and circulating gastric parietal cell autoantibodies. The parietal cell autoantigens have recently been identified as the alpha and beta subunit of the gastric proton pump (H+, K+ ATPase). Here Paul Gleeson and Ban-Hock Toh discuss how the identification of these gastric parietal cell autoantigens and the development of a mouse model of autoimmune gastritis have paved the way for an understanding of the pathogenesis of the gastric lesion.
自身免疫性胃炎可导致恶性贫血，是一种器官特异性自身免疫性疾病，其特征为慢性萎缩性胃炎和循环胃壁细胞自身抗体。胃壁细胞自身抗原最近已被鉴定为胃质子泵（H⁺，K⁺ ATP酶）的α和β亚基。在此，保罗·格利森和陈万福讨论了这些胃壁细胞自身抗原的鉴定以及自身免疫性胃炎小鼠模型的建立如何为理解胃部病变的发病机制铺平了道路。
