裸鼠中人肝癌细胞产生的异常凝血酶原II的检测。
Detection of PIVKA II produced by human hepatoma cells in nude mice.
作者信息
Kohda H, Ono M, Sekiya C, Ohta H, Ohhira M, Ohhira M, Yoshida Y, Ikeda N, Namiki M
机构信息
Third Department of Internal Medicine, Asahikawa Medical College.
出版信息
Hum Cell. 1991 Mar;4(1):63-6.
A novel experimental nude mouse model, which is useful for investigation of the mechanisms of PIVKA II synthesis, was established by inoculation with PIVKA II-producing human hepatoma cells (huH-1). We have found markedly elevated levels of PIVKA II in the plasma of nude mice transplanted with huH-1 cells and increased PIVKA II content in huH-1 tumor tissues. Whereas we have not found detectable level of PIVKA II neither in the plasma nor in tumor tissues of nude mice transplanted different human hepatoma cells (HLF) which is not producing PIVKA II. Histology of the tumor tissues produced by huH-1 cells revealed a thick trabecular pattern with blood spaces.
通过接种产生异常凝血酶原II（PIVKA II）的人肝癌细胞（huH-1），建立了一种新型实验性裸鼠模型，该模型有助于研究PIVKA II的合成机制。我们发现，移植了huH-1细胞的裸鼠血浆中PIVKA II水平显著升高，且huH-1肿瘤组织中PIVKA II含量增加。而在移植了不产生PIVKA II的不同人肝癌细胞（HLF）的裸鼠血浆和肿瘤组织中，我们均未检测到PIVKA II。huH-1细胞产生的肿瘤组织的组织学检查显示出带有血窦的粗大小梁模式。
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