Ono M, Kohda H, Naraki T, Ohta H, Ohhira M, Sekiya C, Namiki M
Third Department of Internal Medicine, Asahikawa Medical College, Japan.
Gastroenterol Jpn. 1992 Dec;27(6):745-50. doi: 10.1007/BF02806527.
Effects of several cytokines on des-gamma-carboxy prothrombin (PIVKA II) synthesis in human hepatoma cells were investigated to know the process of PIVKA II production during a liver allograft rejection. Human recombinant interleukin-6 (IL-6) significantly stimulated the PIVKA II synthesis without any influence on the cell proliferation. The effect was almost completely neutralized by the specific anti-IL-6 antibody. Neither tumor necrosis factor (TNF), interleukin-1 (IL-1) nor interferon-gamma (IFN-gamma) had such a stimulative effect. IL-6 appears to stimulate PIVKA II production, and would be a candidate of factors that enhance the production of PIVKA II during a liver allograft rejection.
研究了几种细胞因子对人肝癌细胞中去γ-羧基凝血酶原（PIVKA II）合成的影响，以了解肝移植排斥反应期间PIVKA II的产生过程。人重组白细胞介素-6（IL-6）显著刺激PIVKA II的合成，而对细胞增殖没有任何影响。该作用几乎完全被特异性抗IL-6抗体中和。肿瘤坏死因子（TNF）、白细胞介素-1（IL-1）和干扰素-γ（IFN-γ）均无这种刺激作用。IL-6似乎刺激PIVKA II的产生，并且可能是在肝移植排斥反应期间增强PIVKA II产生的因子之一。
