Okuyama Katsushi, Nakata Takashi, Pereira Patricia N R, Kawamoto Chiharu, Komatsu Hisanori, Sano Hidehiko
Department of Restorative Dentistry, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan.
Oper Dent. 2006 Jan-Feb;31(1):135-42. doi: 10.2341/0361-7734(2006)31[135:POACEO]2.0.CO;2.
This study investigated the effect of fluoride containing resin composites and bonding agents, as well as the topical fluoride (F) application on the inhibition of artificial caries progression by using a pH-cycling model with alternating demineralizing (pH:4.5) and remineralizing (pH:7.0) solutions. Two bonding systems (F-containing bonding system [Reactmer Bond: RB] and non-F containing bonding system [Clearfil SE Bond: SE]), two resin composites, (F-containing [Reactmer Paste: RP] and non-F containing [Clearfil AP-X: AP]) were used. A combination of each bonding agent and a resin composite, RB+RP, RB+AP, SE+RP and SE+AP, was placed in 2 x 3 x 1.5-mm cavities on root dentin of extracted molars (n=96). Specimens were subjected to pH-cycling for 6 or 12 weeks. Half of all specimens were immersed in 0.05% NaF solution for 1 minute once a day as a topical F application. After the pH cycling period, a microradiograph of each specimen was taken, and the outer lesion depth of the artificial caries was measured by means of image analyzing software. The depths of the outer lesions at different periods were analyzed by one-way ANOVA and Sheffe's test at p=0.05. The combination that received F treatment showed reduced lesion depth compared to the same combination without F application. Except for the F application group of 12 weeks, there was no significant difference in lesion depth among each bonding and composite combination (p>0.05). At week 12 with the F application, RB+RP showed the shallowest lesion compared to the other combinations (p<0.05). The results indicated that the F application reduced the progression of artificial caries. Moreover, the combination of fluoride containing bonding agent and restorative material was the most effective for the inhibition of artificial caries progression based on the 12-week experimental period with topical F application.
本研究采用pH循环模型，通过交替使用脱矿溶液（pH：4.5）和再矿化溶液（pH：7.0），研究含氟树脂复合材料和粘结剂以及局部应用氟化物（F）对抑制人工龋进展的影响。使用了两种粘结系统（含氟粘结系统[Reactmer Bond：RB]和不含氟粘结系统[Clearfil SE Bond：SE]）、两种树脂复合材料（含氟[Reactmer Paste：RP]和不含氟[Clearfil AP-X：AP]）。将每种粘结剂与树脂复合材料的组合，即RB+RP、RB+AP、SE+RP和SE+AP，置于拔除磨牙牙根牙本质上2×3×1.5毫米的窝洞中（n=96）。标本进行6周或12周的pH循环。所有标本的一半每天浸入0.05%氟化钠溶液中1分钟，作为局部氟应用。在pH循环期后，对每个标本进行微射线照相，并使用图像分析软件测量人工龋的外层病变深度。不同时期外层病变的深度通过单因素方差分析和p=0.05时的谢弗检验进行分析。接受氟治疗的组合与未应用氟的相同组合相比，病变深度减小。除12周的氟应用组外，各粘结剂和复合材料组合之间的病变深度无显著差异（p>0.05）。在12周氟应用时，与其他组合相比，RB+RP的病变最浅（p<0.05）。结果表明，氟应用可减少人工龋的进展。此外，基于12周局部氟应用的实验期，含氟粘结剂和修复材料的组合对抑制人工龋进展最有效。
