Bielen E C, Fagard R H, Amery A K
Department of Pathophysiology, Faculty of Medicine, Catholic University of Leuven, Belgium.
J Hypertens. 1991 Jul;9(7):655-63. doi: 10.1097/00004872-199107000-00011.
Thirty-two pairs of monozygotic and 21 pairs of dizygotic male twins aged between 18 and 31 years were studied. Blood pressure was measured and Doppler echocardiography at the level of the aorta was performed in resting conditions and at two levels of supine submaximal bicycle exercise (at a fixed work load of 60 W and at a work load corresponding to a heart rate of 110 beats/min). In resting conditions, a genetic component in the variability of systolic and diastolic blood pressure was found; during submaximal supine exercise only a minor genetic effect was observed. At rest, genetic variance was shown for left ventricular outflow haemodynamics and for peripheral vascular resistance. However, during exercise, the transmissible effect on haemodynamics and peripheral resistance was small.
对32对单卵和21对双卵男性双胞胎进行了研究，他们的年龄在18至31岁之间。测量了血压，并在静息状态以及仰卧位次极量自行车运动的两个水平（固定工作负荷60瓦以及对应心率110次/分钟的工作负荷）下进行了主动脉水平的多普勒超声心动图检查。在静息状态下，发现收缩压和舒张压变异性存在遗传成分；在次极量仰卧运动期间，仅观察到较小的遗传效应。静息时，左心室流出道血流动力学和外周血管阻力显示出遗传方差。然而，在运动期间，对血流动力学和外周阻力的可传递效应较小。
