Logan C M, McCaffrey T A, Wallace J M W, Robson P J, Welch R W, Dunne A, Livingstone M B E
Northern Ireland Centre for Food and Health (NICHE), University of Ulster, Coleraine, UK.
Eur J Clin Nutr. 2006 Sep;60(9):1081-91. doi: 10.1038/sj.ejcn.1602422. Epub 2006 Mar 15.
To investigate the effect of Olibra fat emulsion on medium-term food intake and appetite in non-obese subjects.
Double-blind, placebo-controlled, within-subject crossover.
University of Ulster, Coleraine.
A total of 28 subjects (14 male, 14 female).
Subjects were randomly assigned to receive either a 200 g portion of test (5 g of Olibra fat) or control (5 g milk fat) yoghurt for breakfast for 2 x 3 week 'study' phases, separated by a 3-week 'wash-out' phase. On days 1, 8 and 22 of the study phases, food intake 4 h post-consumption of the yoghurt was assessed by pre- and post-covert weighing at an ad libitum buffet-style test lunch. Throughout each of these study days, appetite was assessed using visual analogue scales (VAS) at regular intervals. For the remainder of the study days, and the following 24 h ('post-study days'), subjects reported their food intake using weighed dietary records.
Consumption of the Olibra emulsion had no significant effect on mean energy, macronutrient or amounts of food consumed at the lunch 4 h post-consumption. Self-reported food intakes indicated that there was no significant effect of the emulsion on energy intakes for the remainder of each study day and post-study days. There was considerable individual variation in food intakes following consumption of the Olibra emulsion, with 46, 59 and 57% of subjects reducing their energy intakes at lunch on days 1, 8 and 22. There was no consistent effect of the emulsion on appetite ratings.
In contrast to earlier studies, there was no evidence of a short- or medium-term effect of the Olibra emulsion on food intake or appetite. This could be owing to numerous confounding factors influencing eating behaviour and/or the different study design used in the present study.
研究奥利司他脂肪乳剂对非肥胖受试者中期食物摄入量和食欲的影响。
双盲、安慰剂对照、受试者自身交叉试验。
科尔雷恩阿尔斯特大学。
共28名受试者（14名男性，14名女性）。
受试者被随机分配，在两个为期3周的“研究”阶段中，早餐分别食用200克试验酸奶（含5克奥利司他脂肪）或对照酸奶（含5克乳脂肪），两个阶段之间有一个为期3周的“洗脱”期。在研究阶段的第1天、第8天和第22天，通过在随意的自助式试验午餐前和午餐后秘密称重来评估食用酸奶4小时后的食物摄入量。在这些研究日的每一天，定期使用视觉模拟量表（VAS）评估食欲。在研究日的其余时间以及接下来的24小时（“研究后日”），受试者使用称重饮食记录报告他们的食物摄入量。
食用奥利司他乳剂对食用后4小时午餐时的平均能量、常量营养素或食物摄入量没有显著影响。自我报告的食物摄入量表明，该乳剂对每个研究日的其余时间和研究后日的能量摄入量没有显著影响。食用奥利司他乳剂后，食物摄入量存在相当大的个体差异，在第1天、第8天和第22天，分别有46%、59%和57%的受试者午餐时能量摄入量减少。该乳剂对食欲评分没有一致的影响。
与早期研究相反，没有证据表明奥利司他乳剂对食物摄入量或食欲有短期或中期影响。这可能是由于众多影响饮食行为的混杂因素和/或本研究中使用的不同研究设计所致。
