Viney M E
School of Biological Sciences, University of Bristol, Woodland Road, BS8 1UG, Bristol, UK.
Med Microbiol Immunol. 2006 Jun;195(2):49-54. doi: 10.1007/s00430-006-0013-2. Epub 2006 Mar 15.
Parasitic nematodes are widespread and important pathogens of humans and other animals. The parasitic nematodes Strongyloides have an unusual life cycle in which there is a facultative free-living generation in addition to the obligate parasitic generation. The genomes of many species of parasitic nematodes, including Strongyloides ratti and Strongyloides stercoralis, have been investigated, principally by expressed sequence tag (EST) analyses. These have discovered very many genes from these parasites but, in so doing, have also revealed how different these species are from each other and from other organisms. Understanding the role and function of these newly discovered genes is now the challenge, made more difficult by the parasitic lifestyle. The genomic information available for parasitic nematodes is allowing new approaches for the control of parasitic nematodes to be considered.
寄生线虫是广泛存在且对人类和其他动物十分重要的病原体。寄生线虫类圆线虫具有独特的生命周期，除了 obligate 寄生世代外，还有一个兼性自由生活世代。包括鼠类圆线虫和粪类圆线虫在内的许多寄生线虫物种的基因组已被研究，主要是通过表达序列标签（EST）分析。这些研究从这些寄生虫中发现了非常多的基因，但与此同时，也揭示了这些物种彼此之间以及与其他生物的差异程度。了解这些新发现基因的作用和功能是目前面临的挑战，而寄生生活方式使这一挑战变得更加困难。寄生线虫的基因组信息为考虑控制寄生线虫的新方法提供了可能。
