Cho-Chung Y S, Clair T, Tortora G, Yokozaki H
Cellular Biochemistry Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Pharmacol Ther. 1991;50(1):1-33. doi: 10.1016/0163-7258(91)90071-s.
Two isoforms of cAMP receptor protein, RI and RII, the regulatory subunits of cAMP-dependent protein kinase, transduce opposite signals, the RI being stimulatory and the RII being inhibitory of cell proliferation. In normal cells RI and RII exist at a specific physiological ratio whereas in cancer cells such physiological balance of these receptor proteins is disrupted. Reversal and suppression of malignancy can be achieved when the physiologic ratio of these intracellular signal transducers of cAMP is restored as shown by the use of site-selective cAMP analogs, antisense oligodeoxynucleotides or gene transfer, suggesting new approaches to cancer control.
环磷酸腺苷（cAMP）受体蛋白的两种同工型，RI和RII，即cAMP依赖性蛋白激酶的调节亚基，传递相反的信号，RI具有刺激作用，而RII则抑制细胞增殖。在正常细胞中，RI和RII以特定的生理比例存在，而在癌细胞中，这些受体蛋白的生理平衡被打破。当通过使用位点选择性cAMP类似物、反义寡脱氧核苷酸或基因转移恢复这些cAMP细胞内信号转导分子的生理比例时，恶性肿瘤可以被逆转和抑制，这提示了癌症控制的新方法。
