Cho-Chung Y S
Cellular Biochemistry Section, National Cancer Institute, NIH, Bethesda, Maryland 20892.
Cancer Res. 1990 Nov 15;50(22):7093-100.
Two isoforms of the regulatory subunits of cyclic AMP (cAMP)-dependent protein kinase that bind cAMP are inversely expressed during ontogeny and cell differentiation. These cAMP-binding receptor proteins in harmony may regulate the growth of normal cells and their differentiation into nondividing states. Cancer cells can also be made to differentiate and stop growing when the functional balance of these cAMP receptor proteins is restored by treatment with site-selective cAMP analogues or by the use of an antisense oligodeoxynucleotide, suggesting new approaches to cancer treatment.
环磷酸腺苷（cAMP）依赖性蛋白激酶调节亚基的两种与cAMP结合的同工型在个体发育和细胞分化过程中呈反向表达。这些协同作用的cAMP结合受体蛋白可能调节正常细胞的生长及其向非分裂状态的分化。当通过位点选择性cAMP类似物治疗或使用反义寡脱氧核苷酸恢复这些cAMP受体蛋白的功能平衡时，癌细胞也可被诱导分化并停止生长，这提示了癌症治疗的新方法。
