Miller W R, Watson D M, Jack W, Chetty U, Elton R A
ICRF Medical Oncology Unit, Western General Hospital, Edinburgh, U.K.
Breast Cancer Res Treat. 1993;26(1):89-94. doi: 10.1007/BF00682703.
In two separate cohorts of breast cancer patients presenting without evidence of distant metastatic disease, high levels of tumour cyclic AMP binding proteins (> 8 pmol/mg cytosol protein) have been shown to be associated with poor prognosis in terms of both disease recurrence and overall survival. This association is independent of known established prognostic factors and allows the identification of a small subgroup of patients whose outlook warrants the implementation of aggressive systemic therapy.
在两组初诊时无远处转移证据的乳腺癌患者中，已显示高水平的肿瘤环磷酸腺苷结合蛋白（>8 pmol/mg胞浆蛋白）与疾病复发和总生存期方面的不良预后相关。这种关联独立于已知的既定预后因素，并且能够识别出一小部分患者亚组，其预后情况表明需要实施积极的全身治疗。
