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[脊髓接种脊髓灰质炎疫苗病毒的猴子的中枢神经系统病变]

[The CNS lesion in monkeys spinally infected with the vaccinal poliomyelitis virus].

作者信息

Tereshkina N V, Lavrova I K, Kozlov V G, Sobolev S G, Tiufanov A V, Koroleva G A, Grigor'eva L V, Chigirinskiĭ A E

出版信息

Vopr Virusol. 1991 May-Jun;36(3):222-6.

PMID:1654009
Abstract

Specific features of the CNS lesions in monkeys inoculated with a vaccine poliovirus strain were studied in comparison with those developing after inoculation with virulent strains. The lesions in the lumbar cord and other regions of the brain and spinal cord after intraspinal inoculation of the vaccine virus are described at length. Certain signs reflecting the specific nature of the lesions were observed. The results of histopathological and immunofluorescent studies were shown to be important for differentiation of specific and nonspecific lesions.

摘要

研究了接种脊髓灰质炎疫苗病毒株的猴子中枢神经系统病变的具体特征,并与接种强毒株后出现的病变进行了比较。详细描述了脊髓内接种疫苗病毒后脊髓腰段及脑和脊髓其他区域的病变。观察到了反映病变特异性的某些体征。结果表明,组织病理学和免疫荧光研究结果对于区分特异性和非特异性病变很重要。

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