• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

脊髓灰质炎病毒3型毒株经猴中枢神经系统传代后的特性

Characteristics of poliovirus type 3 strains after passage through monkey central nervous system.

作者信息

Jarzabek Z J, Sadowski W, Janicki P

出版信息

Acta Virol. 1977 Jan;21(1):57-62.

PMID:15438
Abstract

Cercopithecus aethiops monkeys were inoculated intracerebrally with Sabin's type 3 polivoirus strain, and with strains isolated from subjects vaccinated with Leon 12a1b and from their contacts. Sample of brain, spinal cord, kidneys, lymph nodes, blood and spinal fluid were taken. From these materials, (except of kidneys) 23 poliovirus strains of type 3 were isolated. Genetic markers rct 40.3, rct 41, d and IST were determined for these strains. The changes observed in genetic markers of strains passaged through the cental nervous system (CNS) of monkeys are described.

摘要

将黑猩猩脑内接种萨宾 3 型脊髓灰质炎病毒株,以及从接种了莱昂 12a1b 的受试者及其接触者中分离出的毒株。采集脑、脊髓、肾脏、淋巴结、血液和脑脊液样本。从这些材料(肾脏除外)中分离出 23 株 3 型脊髓灰质炎病毒株。测定了这些毒株的遗传标记 rct 40.3、rct 41、d 和 IST。描述了在猴中枢神经系统(CNS)中传代的毒株遗传标记中观察到的变化。

相似文献

1
Characteristics of poliovirus type 3 strains after passage through monkey central nervous system.脊髓灰质炎病毒3型毒株经猴中枢神经系统传代后的特性
Acta Virol. 1977 Jan;21(1):57-62.
2
Studies on the characteristics of Poliovirus type 3. III. Strain characteristics after passage in man.脊髓灰质炎3型病毒特性研究。III. 在人体传代后的毒株特性
Acta Virol. 1976 Oct;20(5):373-9.
3
Studies on the characteristics of poliovirus type 3. II. Characteristics of "hot" clones.3型脊髓灰质炎病毒特性的研究。II. “热”克隆的特性。
Acta Virol. 1976 Oct;20(5):366-72.
4
[The CNS lesion in monkeys spinally infected with the vaccinal poliomyelitis virus].[脊髓接种脊髓灰质炎疫苗病毒的猴子的中枢神经系统病变]
Vopr Virusol. 1991 May-Jun;36(3):222-6.
5
High and prolonged incidence of poliovirus strains during 1979 in North Bohemia. Isolations from unusual materials.1979年期间北波希米亚地区脊髓灰质炎病毒株的高发病率及持续时间。来自异常材料的分离株。
Zentralbl Bakteriol Mikrobiol Hyg A Med Mikrobiol Infekt Parasitol. 1981 Dec;251(1):1-14.
6
[Studies on safety tests of inactivated poliomyelitis vaccines. IV. Comparative safety tests in rhesus monkeys and long-tailed monkeys (Cercopithecus aethiops)].[灭活脊髓灰质炎疫苗安全性试验研究。IV. 恒河猴和长尾猴(埃塞俄比亚猕猴)的比较安全性试验]
Zentralbl Bakteriol Orig. 1966 Jun;200(2):137-50.
7
Neurovirulence of the intertypic poliovirus recombinant v3/a1-25: characterization of strains isolated from the spinal cord of diseased monkeys and evaluation of the contribution of the 3' half of the genome.
J Gen Virol. 1985 Feb;66 ( Pt 2):309-16. doi: 10.1099/0022-1317-66-2-309.
8
[Studies on safety tests of inactivated poliomyelitis vaccines. V. Pathomorphological changes in the CNS of rhesus monkeys (Macaca rhesus) and long-tailed monkeys (Cercopithecus aethiops) following intracerebral and intralumbar inoculation with inactivated poliovirus types I, II, and 3].[灭活脊髓灰质炎疫苗的安全性试验研究。V. 恒河猴(猕猴属)和长尾猴(埃塞俄比亚猕猴)脑内和腰椎注射I、II和3型灭活脊髓灰质炎病毒后中枢神经系统的病理形态学变化]
Zentralbl Bakteriol Orig. 1966 Jun;200(2):150-66.
9
Limited in vivo susceptibility of the South American monkey -Cebus apella- to type 1 poliovirus: physical and histopathological observations after intraspinal inoculation.南美猴子——僧帽猴对1型脊髓灰质炎病毒的体内易感性有限:脊髓内接种后的物理和组织病理学观察
Biken J. 1985 Jun;28(1-2):21-30.
10
Succession of mutations in the Sabin strain of type 3 poliovirus replicating in the central nervous system of monkeys.在猴子中枢神经系统中复制的3型脊髓灰质炎病毒萨宾株的突变序列。
Virology. 1996 Jun 15;220(2):285-9. doi: 10.1006/viro.1996.0316.