Rodríguez-Avial Iciar, Rodríguez-Avial Carmen, López Olga, Culebras Esther, Picazo Juan J
Servicio de Microbiología, Hospital Clínico San Carlos, Plaza de Cristo Rey s/n, 28040 Madrid, Spain.
Int J Antimicrob Agents. 2006 Apr;27(4):303-6. doi: 10.1016/j.ijantimicag.2005.11.016. Epub 2006 Mar 15.
During 2003 in our hospital, 236 clinical faecal Campylobacter spp. were isolated, of which 166 (70%) were resistant to tetracycline and 199 (84%) were resistant to ciprofloxacin by the disk diffusion method. Resistance to both antimicrobial agents was found in 146 isolates (62%). The in vitro activity of tigecycline was compared with that of erythromycin, clindamycin and amoxicillin/clavulanic acid using the agar dilution method against 116 selected Campylobacter spp. that were resistant to both tetracycline and ciprofloxacin. The minimum inhibitory concentration at which 90% of the isolates were inhibited (MIC90) was 0.06 mg/L for tigecycline and 4, 2 and 1 microg/mL for amoxicillin/clavulanic acid, erythromycin and clindamycin, respectively. The high in vitro activity of tigecycline against tetracycline- and ciprofloxacin-resistant strains suggests a potential therapeutic role in the treatment of infections that involve Campylobacter spp.
2003年在我院，共分离出236株临床粪便弯曲杆菌，其中166株（70%）对四环素耐药，199株（84%）通过纸片扩散法检测对环丙沙星耐药。146株（62%）对这两种抗菌药物均耐药。采用琼脂稀释法，将替加环素与红霉素、克林霉素和阿莫西林/克拉维酸的体外活性进行比较，针对116株对四环素和环丙沙星均耐药的弯曲杆菌。替加环素对90%菌株产生抑制的最低抑菌浓度（MIC90）为0.06mg/L，阿莫西林/克拉维酸、红霉素和克林霉素的MIC90分别为4、2和1μg/mL。替加环素对四环素和环丙沙星耐药菌株的高体外活性表明其在治疗涉及弯曲杆菌的感染中具有潜在治疗作用。
