Berardi C, Wheaton L G, Twardock A R, Schaeffer D J
Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana 61801.
Am J Vet Res. 1991 Jul;52(7):1089-96.
A nuclear imaging technique of the stomach, using technetium pertechnetate (99mTcO4), was evaluated in healthy dogs. The stomach was first insufflated with room air, then filled with barium sulfate to induce mild distention, outlining the gastric wall. Six dogs were imaged twice: initially without use of drugs that might affect gastric secretion of 99mTcO4, then after pretreatment with cimetidine and glycopyrrolate. These scans established the appearance of the normal (control) stomach and compared the quality of the image in the same dogs not pretreated, then pretreated with cimetidine and glycopyrrolate before administration of 99mTcO4. Avascular defects were then surgically created on the greater curvature of the stomach of the same 6 dogs, and gastroscintigraphy was performed in similar manner. Significant (P less than 0.05) quantitative differences were detected in the gastric images for scans of the avascular area, compared with various control scans. Qualitative assessment had overall accuracy of 90.28%. Results of the study reported here indicate that nuclear imaging can be a valuable diagnostic technique for detecting ischemic areas in the gastric wall of dogs.
利用高锝酸盐（99mTcO4）对健康犬的胃进行核成像技术评估。首先向胃内注入室内空气，然后填充硫酸钡以引起轻度扩张，勾勒出胃壁轮廓。6只犬进行了两次成像：最初在不使用可能影响99mTcO4胃分泌的药物的情况下成像，然后在西咪替丁和格隆溴铵预处理后成像。这些扫描确定了正常（对照）胃的外观，并比较了同一批犬在未预处理、在注射99mTcO4前用西咪替丁和格隆溴铵预处理后的图像质量。然后在同6只犬的胃大弯处手术制造无血管缺损，并以类似方式进行胃闪烁显像。与各种对照扫描相比，在无血管区域扫描的胃图像中检测到显著（P<0.05）的定量差异。定性评估的总体准确率为90.28%。本文报道的研究结果表明，核成像可作为检测犬胃壁缺血区域的有价值的诊断技术。
