Berardi C, Twardock A R, Wheaton L G, Schaeffer D J
Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana 61801.
Am J Vet Res. 1991 Jul;52(7):1081-8.
To evaluate the use of technetium pertechnetate (99mTcO4) as a means of estimating gastric mucosal integrity, nuclear images of the empty stomach were obtained from 6 dogs at 20, 40, 60, 120, 180, and 240 minutes after IV administration of the radiopharmaceutical. Blood and gastric secretion samples were collected during the same time intervals. The left lateral-view image of the stomach was used to calculate the relative fraction of the dose in the stomach and the count density ratio. Between 20 and 40 minutes and 40 and 60 minutes, significant differences (P less than 0.001) were apparent in the amount of 99mTcO4 in the stomach. Blood concentration of 99mTcO4 decreased significantly (P less than 0.001), whereas gastric secretion concentration increased significantly (P less than 0.001) over time. Qualitative assessment of the gastric nuclear scans and the statistical analytic results indicated that the optimal time for imaging the canine stomach was between 40 and 60 minutes after radiopharmaceutical administration. In a second study, the same dogs were pretreated with the H2-receptor antagonist cimetidine and the cholinergic antagonist glycopyrrolate to block gastric secretions. Over time, changes in the relative dose fraction in the stomach and the density ratio were the same as values obtained during the experiment performed without use of cimetidine and glycopyrrolate. Results of the study indicate that nuclear imaging with 99mTcO4 outlines normal canine gastric mucosa and that pretreatment with cimetidine and glycopyrrolate has no effect on the quality of the gastric image.
为评估高锝酸盐（99mTcO4）作为估计胃黏膜完整性方法的应用，在静脉注射放射性药物后20、40、60、120、180和240分钟，从6只犬获取空腹胃的核素图像。在相同时间间隔采集血液和胃分泌样本。利用胃的左侧位图像计算胃内剂量的相对分数和计数密度比。在20至40分钟以及40至60分钟之间，胃内99mTcO4的量存在显著差异（P小于0.001）。随着时间推移，99mTcO4的血药浓度显著降低（P小于0.001），而胃分泌浓度显著升高（P小于0.001）。对胃核素扫描的定性评估和统计分析结果表明，对犬胃进行成像的最佳时间是在注射放射性药物后40至60分钟之间。在第二项研究中，对同一只犬预先给予H2受体拮抗剂西咪替丁和胆碱能拮抗剂格隆溴铵以阻断胃分泌。随着时间推移，胃内相对剂量分数和密度比的变化与未使用西咪替丁和格隆溴铵进行实验时获得的值相同。研究结果表明，99mTcO4核素成像可勾勒出正常犬胃黏膜，并且西咪替丁和格隆溴铵预处理对胃图像质量无影响。
