O'Connor M K, O'Connell R, Keane F B, Byrne P J, Hennessy T P
Br J Radiol. 1983 Nov;56(671):817-22. doi: 10.1259/0007-1285-56-671-817.
In order to elucidate the gastric handling of 99Tcm, we performed scintiscanning under basal and stimulated conditions while simultaneously monitoring gastric outputs of water and sodium, hydrogen and 99Tcm pertechnetate ions in six healthy fasting volunteers. Our results showed that gastric scintiscanning correlated well with gastric luminal 99Tcm activity (r = 0.99). However, clearance of 99Tcm from plasma into the gastric lumen showed only a poor correlation with hydrogen ion output (r = 0.68) and no correlation with sodium output. Explanation of these results on a cellular basis can be achieved by assuming a two-component mechanism for 99Tcm secretion, with both the parietal cells (H+ ion secretory) and non-parietal cells (Na+ ion secretory) contributing to 99Tcm gastric output. The relative contribution of each cell type to total 99Tcm secretion is dependent on the degree of gastric stimulation, with non-parietal 99Tcm secretion dominating in the basal state and parietal 99Tcm secretion dominating in the stimulated state. It is concluded therefore, that gastric scintiscanning with 99Tcm pertechnetate should stand only as an empirical test of gastric function and not as a means of measuring acid output.
为了阐明99锝在胃内的处理情况，我们在基础状态和刺激状态下对6名健康的空腹志愿者进行了闪烁扫描，同时监测水、钠、氢离子和高锝酸根离子的胃排出量。我们的结果表明，胃闪烁扫描与胃腔内99锝活性密切相关（r = 0.99）。然而，99锝从血浆清除进入胃腔与氢离子排出量的相关性较差（r = 0.68），与钠排出量无相关性。通过假设99锝分泌的双组分机制，可以从细胞层面解释这些结果，壁细胞（分泌氢离子）和非壁细胞（分泌钠离子）均对99锝的胃排出有贡献。每种细胞类型对99锝总分泌的相对贡献取决于胃刺激的程度，在基础状态下非壁细胞的99锝分泌占主导，在刺激状态下壁细胞的99锝分泌占主导。因此得出结论，用高锝酸盐进行胃闪烁扫描仅应作为胃功能的经验性测试，而不应作为测量胃酸排出量的手段。
