Toumbis M, Zervas J, Anagnostopoulou O, Konstantopoulos K, Krimbeni G, Kotsovoulou V, Fessas F
Second Department of Chest Medicine, Athens Hospital of Chest Diseases, Greece.
Acta Oncol. 1991;30(5):575-8. doi: 10.3109/02841869109092420.
The distribution of HLA antigens was studied in 85 Greek patients with bronchogenic carcinoma. Fifty-seven specific HLA antisera were used to determine 27 HLA-A and B antigens, with the two-stage standard NIH microlymphocytotoxicity assay. The results were compared with those in a control group, consisting of 400 healthy individuals. In the whole group of patients there was a significantly higher frequency of HLA-AW19 and HLA-A29 (p less than 0.003 and p less than 0.006 respectively) and a lower frequency of HLA-A2 and HLA-A3 (p less than 0.014 and p less than 0.006 respectively) than in the control population. In patients with squamous cell carcinoma there was a significantly higher frequency of HLA-AW19 and lower frequency of HLA-A2 (p less than 0.02 and p less than 0.05 respectively). In small cell carcinoma patients there was a significantly lower frequency of HLA-A3 (p less than 0.04) than among the controls. In patients with adenocarcinoma no significant change of HLA antigen frequencies was observed when compared to the controls.
对85例希腊支气管癌患者的HLA抗原分布情况进行了研究。采用两阶段标准的美国国立卫生研究院微量淋巴细胞毒性试验，用57种特异性HLA抗血清来测定27种HLA - A和B抗原。将结果与由400名健康个体组成的对照组进行比较。在整个患者组中，HLA - AW19和HLA - A29的频率显著更高（分别为p < 0.003和p < 0.006），而HLA - A2和HLA - A3的频率则低于对照组（分别为p < 0.014和p < 0.006）。在鳞状细胞癌患者中，HLA - AW19的频率显著更高，而HLA - A2的频率更低（分别为p < 0.02和p < 0.05）。在小细胞癌患者中，HLA - A3的频率显著低于对照组（p < 0.04）。与对照组相比，腺癌患者的HLA抗原频率未观察到显著变化。
