Prazák J, Mĕricka O
Institute of Hematology and Blood Transfusion, Prague, Czechoslovakia.
Neoplasma. 1989;36(5):599-602.
Twenty-one HLA-A and B antigens were determined in a study of 162 patients with lung cancer. Differences between antigen frequencies in cancer and control populations were determined by chi 2 analysis with Yates correction or Fisher's exact test. Cancer patients had a decreased frequency of the antigen HLA-B40 (pc = 0.003; relative risk = 0.21). In patients with differentiated types of the carcinoma and relatively better prognosis, decreased frequency of the antigen HLA-B40 was found (pc = 0.05; relative risk = 0.27). Our investigation was based on a thorough study of literary data.
在一项对162名肺癌患者的研究中测定了21种HLA - A和B抗原。通过采用Yates校正的卡方分析或Fisher精确检验来确定癌症患者群体与对照群体中抗原频率的差异。癌症患者中抗原HLA - B40的频率降低（pc = 0.003；相对风险 = 0.21）。在分化型癌且预后相对较好的患者中，发现抗原HLA - B40的频率降低（pc = 0.05；相对风险 = 0.27）。我们的研究基于对文献数据的全面研究。
