Pattingre Sophie, Levine Beth
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA.
Cancer Res. 2006 Mar 15;66(6):2885-8. doi: 10.1158/0008-5472.CAN-05-4412.
Bcl-2 was the first identified cellular protein that functions as an oncogene by blocking apoptotic cell death. Beclin 1, the first identified mammalian autophagy gene product, is a haploinsufficient tumor suppressor that was originally isolated as a Bcl-2-interacting protein. We recently showed that Bcl-2 negatively regulates Beclin 1-dependent autophagy and Beclin 1-dependent autophagic cell death. These findings raise the possibility that Bcl-2 family members may function as oncogenes not only by blocking apoptosis but also by blocking autophagy.
Bcl-2是首个被鉴定出的通过阻断凋亡性细胞死亡而发挥癌基因功能的细胞蛋白。Beclin 1是首个被鉴定出的哺乳动物自噬基因产物，是一种单倍体不足的肿瘤抑制因子，最初作为一种与Bcl-2相互作用的蛋白被分离出来。我们最近发现，Bcl-2负向调节Beclin 1依赖的自噬和Beclin 1依赖的自噬性细胞死亡。这些发现提示，Bcl-2家族成员可能不仅通过阻断凋亡，还通过阻断自噬而发挥癌基因的功能。
