血清胸苷激酶、组织多肽抗原和神经元特异性烯醇化酶在小细胞肺癌患者中的预后价值。
Prognostic value of serum thymidine kinase, tissue polypeptide antigen and neuron specific enolase in patients with small cell lung cancer.
作者信息
van der Gaast A, van Putten W L, Oosterom R, Cozijnsen M, Hoekstra R, Splinter T A
机构信息
Department of Medical Oncology, University Hospital Rotterdam-Dijkzigt, The Netherlands.
出版信息
Br J Cancer. 1991 Aug;64(2):369-72. doi: 10.1038/bjc.1991.309.
Abstract
In a group of seventy patients with small cell lung cancer the prognostic value of serum tumour markers was determined. Thymidine kinase (TK), tissue polypeptide antigen (TPA) and lactate dehydrogenase (LDH) but not neuron specific enolase (NSE) correlated significantly with survival. Since all markers were strongly interrelated with each other and with the extent of disease, the combined determination of TK, TPA and LDH or the combination of disease extent and a marker yielded no more prognostic information than a single measurement of one of these variables.
摘要
在一组70例小细胞肺癌患者中，测定了血清肿瘤标志物的预后价值。胸苷激酶（TK）、组织多肽抗原（TPA）和乳酸脱氢酶（LDH）与生存率显著相关，但神经元特异性烯醇化酶（NSE）与生存率无显著相关性。由于所有标志物彼此之间以及与疾病范围都密切相关，因此联合测定TK、TPA和LDH，或者将疾病范围与一种标志物联合起来，所提供的预后信息并不比单独测量这些变量之一更多。
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本文引用的文献
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Int J Cancer. 1984 Jan 15;33(1):5-12. doi: 10.1002/ijc.2910330103.
2
Prognostic factors in small cell carcinoma of the lung: a cancer and leukemia group B study.肺癌小细胞癌的预后因素：癌症与白血病B组研究
Cancer Treat Rep. 1981 Sep-Oct;65(9-10):767-74.
3
Serum neuron-specific enolase: a marker for disease extent and response to therapy of small-cell lung cancer.血清神经元特异性烯醇化酶：小细胞肺癌疾病范围及治疗反应的标志物。
Lancet. 1982 Mar 13;1(8272):583-5. doi: 10.1016/s0140-6736(82)91748-2.
4
Tumor markers in bronchogenic carcinoma. Superiority of tissue polypeptide antigen to carcinoembryonic antigen and carbohydrate antigenic determinant 19-9.支气管源性癌中的肿瘤标志物。组织多肽抗原相对于癌胚抗原和糖类抗原决定簇19-9的优势。
Cancer. 1987 Jul 1;60(1):42-50. doi: 10.1002/1097-0142(19870701)60:1<42::aid-cncr2820600109>3.0.co;2-3.
5
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6
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7
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