van der Gaast A, van Putten W L, Oosterom R, Cozijnsen M, Hoekstra R, Splinter T A
Department of Medical Oncology, University Hospital Rotterdam-Dijkzigt, The Netherlands.
Br J Cancer. 1991 Aug;64(2):369-72. doi: 10.1038/bjc.1991.309.
In a group of seventy patients with small cell lung cancer the prognostic value of serum tumour markers was determined. Thymidine kinase (TK), tissue polypeptide antigen (TPA) and lactate dehydrogenase (LDH) but not neuron specific enolase (NSE) correlated significantly with survival. Since all markers were strongly interrelated with each other and with the extent of disease, the combined determination of TK, TPA and LDH or the combination of disease extent and a marker yielded no more prognostic information than a single measurement of one of these variables.
在一组70例小细胞肺癌患者中，测定了血清肿瘤标志物的预后价值。胸苷激酶（TK）、组织多肽抗原（TPA）和乳酸脱氢酶（LDH）与生存率显著相关，但神经元特异性烯醇化酶（NSE）与生存率无显著相关性。由于所有标志物彼此之间以及与疾病范围都密切相关，因此联合测定TK、TPA和LDH，或者将疾病范围与一种标志物联合起来，所提供的预后信息并不比单独测量这些变量之一更多。
