Davenport Miles P, Zhang Lei, Shiver John W, Casmiro Danilo R, Ribeiro Ruy M, Perelson Alan S
Department of Haematology, Prince of Wales Hospital and Centre for Vascular Research, University of New South Wales, Kensington, New South Wales, Australia.
J Acquir Immune Defic Syndr. 2006 Mar;41(3):259-65. doi: 10.1097/01.qai.0000199232.31340.d3.
Simian HIV (SHIV) infection of macaques with CXCR4 tropic viruses results in early and profound CD4 T-cell depletion in the first few weeks of infection. Analyzing data from a large study of vaccination and SHIV-89.6P challenge, we observe a strong correlation between peak viral load and the extent of CD4 T-cell depletion in acute infection, consistent with a simple kinetic model of viral infection of CD4 T cells. We have modeled the dynamics of the interaction of virus and CD4 T cells over time to investigate the rate of CD4 T-cell infection and death. This analysis indicates that up to 80% of CD4 T cells are infected at peak viremia and that the proportion of CD4 T cells destroyed is correlated with the peak viral load. The simple relation between viral load and CD4 T-cell depletion allows prediction of the level of viral control required to prevent CD4 T-cell depletion in acute SHIV infection. Whether such a simple relation also holds for HIV or simian immunodeficiency virus infections remains to be determined, particularly in the gut and other anatomic sites in which most early T-cell depletion occurs.
用嗜CXCR4病毒感染猕猴的猿猴免疫缺陷病毒（SHIV），会在感染后的最初几周导致早期且严重的CD4 T细胞耗竭。通过分析一项关于疫苗接种和SHIV - 89.6P攻击的大型研究数据，我们观察到急性感染期间病毒载量峰值与CD4 T细胞耗竭程度之间存在强烈相关性，这与CD4 T细胞病毒感染的简单动力学模型一致。我们对病毒与CD4 T细胞随时间的相互作用动态进行了建模，以研究CD4 T细胞感染和死亡的速率。该分析表明，在病毒血症峰值时高达80%的CD4 T细胞被感染，且被破坏的CD4 T细胞比例与病毒载量峰值相关。病毒载量与CD4 T细胞耗竭之间的这种简单关系使得能够预测在急性SHIV感染中预防CD4 T细胞耗竭所需的病毒控制水平。这种简单关系是否也适用于HIV或猿猴免疫缺陷病毒感染仍有待确定，特别是在肠道和其他大多数早期T细胞耗竭发生的解剖部位。
