Luciak M, Pawlicki L, Kedziora J, Trznadel K, Błaszczyk J, Buczyński A
2nd Department of Internal Medicine, Institute of Internal Medicine, WAM, Lódź, Poland.
Free Radic Biol Med. 1991;10(6):397-401. doi: 10.1016/0891-5849(91)90048-8.
Six chronic uremic patients on regular hemodialysis treatment were given recombinant human erythropoietin (r-huEPO) in a dose of 50 U/kg of body weight intravenously thrice weekly for 14 weeks. Following r-huEPO therapy, unstimulated whole blood superoxide anion (O2) generation did not change significantly, while opsonized zymosan-stimulated whole blood O2 generation increased. At the same time, erythrocyte superoxide dismutase and, in particular, glutathione peroxidase activities were found to be reducing with concomitant lowering of erythrocyte malonyldialdehyde (MDA) concentrations and increase in plasma MDA concentrations.
六名接受定期血液透析治疗的慢性尿毒症患者，每周静脉注射三次重组人促红细胞生成素（r-huEPO），剂量为50 U/kg体重，持续14周。r-huEPO治疗后，未刺激的全血超氧阴离子（O2）生成没有显著变化，而调理酵母聚糖刺激的全血O2生成增加。同时，发现红细胞超氧化物歧化酶，尤其是谷胱甘肽过氧化物酶活性降低，同时红细胞丙二醛（MDA）浓度降低，血浆MDA浓度升高。
