Bongers Thomas, Griffiths Richard D
ICU Whiston Hospital and School of Clinical Science, University of Liverpool, Liverpool, UK.
Curr Opin Crit Care. 2006 Apr;12(2):131-5. doi: 10.1097/01.ccx.0000216580.41933.00.
We know that adequate nutritional support is essential in the treatment of critically ill patients, because it can, if applied appropriately, improve the clinical outcome. Increasing evidence seems to suggest that malnutrition itself is a predictor of poor outcome in intensive care, and significant underfeeding during intensive care stay increases the risk of bloodstream infections. The purpose of this review is to highlight recent advances in enteral nutrition in the critically ill adult patient.
Recent studies suggest that tight glycaemic control is associated with improved outcome. Enteral feeding should be encouraged, using simple feeding protocols, and started early if safe to do so. Gastric residual volumes do not correlate with the risk of aspiration, and therefore should be used with caution in feeding protocols. Conflicting evidence exists for supplementation with antioxidant and immunonutrition in the critically ill. Glutamine and fish oil/borage oil should be considered for burns patients and patients with adult respiratory distress syndrome, respectively.
This review offers information regarding the latest developments in nutritional support via the enteral route. Further research is needed to clarify the role of enteral supplements such as antioxidants and 'immune modulating substances'.
我们知道充足的营养支持在危重症患者治疗中至关重要,因为若应用得当,它可改善临床结局。越来越多的证据似乎表明,营养不良本身是重症监护中预后不良的一个预测因素,而在重症监护期间严重摄入不足会增加血流感染的风险。本综述的目的是强调成年危重症患者肠内营养的最新进展。
近期研究表明,严格控制血糖与改善预后相关。应鼓励采用简单的喂养方案进行肠内喂养,并在安全的情况下尽早开始。胃残余量与误吸风险无关,因此在喂养方案中应谨慎使用。关于危重症患者补充抗氧化剂和免疫营养存在相互矛盾的证据。对于烧伤患者和成人呼吸窘迫综合征患者,应分别考虑补充谷氨酰胺和鱼油/琉璃苣油。
本综述提供了有关肠内营养支持最新进展的信息。需要进一步研究以阐明抗氧化剂和“免疫调节物质”等肠内补充剂的作用。