Hall Caroline Breese, Caserta Mary T, Schnabel Kenneth C, McDermott Michael P, Lofthus Geraldine K, Carnahan Jennifer A, Gilbert Lynne M, Dewhurst Stephen
Department of Pediatrics, and Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.
J Infect Dis. 2006 Apr 15;193(8):1063-9. doi: 10.1086/503434. Epub 2006 Mar 6.
Although both human herpesvirus (HHV) 6 and HHV-7 infections are ubiquitous during childhood, few acute HHV-7 infections are identified. It is unknown whether HHV-7 viremia indicates primary infection, as with HHV-6, or reactivation, and if these differ clinically. We studied, in otherwise healthy children < or =10 years old, HHV-7 and HHV-6 infections and their interaction by serologic assessment, viral isolation, and polymerase chain reaction. In children < or =24 months of age, HHV-7 infections occurred less often than HHV-6 infections (P< or =.002). Of 2806 samples from 2365 children < or =10 years old, 30 (1%) showed evidence of HHV-7 viremia; 23 (77%) of these were primary and 7 (23%) were reactivated HHV-7 infections. Four (13%) showed concurrent HHV-6 viremia, 2 associated with primary HHV-7 infections. The clinical manifestations of primary and reactivated HHV-7 infections were similar, except that seizures occurred more frequently in reactivated infections. These findings, previously unrecognized in otherwise healthy children, suggest that HHV-7 viremia could represent primary or reactivated infection and may be affected by the interaction between HHV-6 and HHV-7.
尽管人类疱疹病毒（HHV）6型和HHV - 7型感染在儿童时期普遍存在，但确诊的急性HHV - 7感染却很少。目前尚不清楚HHV - 7病毒血症是像HHV - 6那样表示原发性感染，还是表示病毒再激活，以及它们在临床上是否存在差异。我们通过血清学评估、病毒分离和聚合酶链反应，对10岁及以下健康儿童的HHV - 7和HHV - 6感染及其相互作用进行了研究。在24个月及以下的儿童中，HHV - 7感染的发生率低于HHV - 6感染（P≤0.002）。在来自2365名10岁及以下儿童的2806份样本中，30份（1%）显示有HHV - 7病毒血症的证据；其中23份（77%）为原发性感染，7份（23%）为HHV - 7再激活感染。4份（13%）显示同时存在HHV - 6病毒血症，其中2份与原发性HHV - 7感染相关。原发性和再激活的HHV - 7感染的临床表现相似，只是癫痫发作在再激活感染中更频繁。这些在其他方面健康的儿童中以前未被认识到的发现表明，HHV - 7病毒血症可能代表原发性或再激活感染，并且可能受到HHV - 6和HHV - 7之间相互作用的影响。
