Tschanz Joann T, Treiber Katherine, Norton Maria C, Welsh-Bohmer Kathleen A, Toone Leslie, Zandi Peter P, Szekely Christine A, Lyketsos Constantine, Breitner John C S
Department of Psychology, Center for Epidemiologic Studies, Utah State University, Logan 84322-4440, USA.
Care Manag J. 2005 Summer;6(2):107-14. doi: 10.1891/cmaj.6.2.107.
There are several population-based studies of aging, memory, and dementia being conducted worldwide. Of these, the Cache County Study on Memory, Health and Aging is noteworthy for its large number of "oldest-old" members. This study, which has been following an initial cohort of 5,092 seniors since 1995, has reported among its major findings the role of the Apolipoprotein E gene on modifying the risk for Alzheimer's disease (AD) in males and females and identifying pharmacologic compounds that may act to reduce AD risk. This article summarizes the major findings of the Cache County study to date, describes ongoing investigations, and reports preliminary analyses on the outcome of the oldest-old in this population, the subgroup of participants who were over age 84 at the study's inception.
全球正在进行多项基于人群的衰老、记忆和痴呆症研究。其中，卡什县记忆、健康与衰老研究因其大量的“最年长者”成员而值得关注。自1995年以来，这项研究一直跟踪最初的5092名老年人队列，其主要研究结果包括载脂蛋白E基因在改变男性和女性患阿尔茨海默病（AD）风险方面的作用，以及确定可能有助于降低AD风险的药物化合物。本文总结了卡什县研究迄今为止的主要研究结果，描述了正在进行的调查，并报告了对该人群中最年长者（即研究开始时年龄超过84岁的参与者亚组）结局的初步分析。
