Tang Ming, Zhang Jing, Chen J D Z
Department of Physiology, Medical College of Qingdao University, China.
Obes Surg. 2006 Mar;16(3):344-52. doi: 10.1381/096089206776116372.
Gastric electrical stimulation (GES) has been shown to be effective in inducing satiety in patients with obesity, as well as in treating nausea and vomiting in patients with gastroparesis. It is conceivable that these effects are mediated via the central nervous system, although there is a lack of studies or evidences. The aims of this study were to investigate the effects of GES with different parameters on neurons in the paraventricular nucleus (PVN) of the hypothalamus and to study whether the neuronal response was related to stimulation parameters.
Extracellular potentials of single neurons in the PVN were recorded in anesthetized rats at baseline, during gastric distention (GD) and during GES with various sets of parameters.
Of 115 PVN neurons tested by GD, 104 were GD-responsive neurons. Most of these GD-responsive neurons were responsive to GES of various parameters. 1) GES with parameters used in treating obesity, activated neurons both excited (GD-E) and inhibited (GD-I) by gastric distention; it excited 48.4% (16/33) of the GD-E neurons and 60.4% (29/48) of GD-I neurons. 2) GES with increased pulse width was of the highest efficacy in exciting the GD-responsive neurons, whereas a reduction in stimulation frequency resulted in a lower activation. 3) GES with parameters used in treating gastroparesis solicited neuronal responses opposite to those with parameters used for treating obesity.
GES activates gastric-related neurons in the PVN, and the excitatory effect of GES seems related to stimulation strength. The GES used for treating gastroparesis and the GES used for treating obesity seem to solicit different neuronal responses in the PVN.
胃电刺激（GES）已被证明对肥胖患者诱导饱腹感有效，对胃轻瘫患者治疗恶心和呕吐也有效。尽管缺乏相关研究或证据，但可以想象这些作用是通过中枢神经系统介导的。本研究的目的是研究不同参数的GES对下丘脑室旁核（PVN）神经元的影响，并研究神经元反应是否与刺激参数有关。
在麻醉大鼠的基础状态、胃扩张（GD）期间以及使用各种参数集进行GES期间，记录PVN中单个神经元的细胞外电位。
在115个接受GD测试的PVN神经元中，104个是GD反应性神经元。这些GD反应性神经元中的大多数对各种参数的GES有反应。1） 用于治疗肥胖症的参数的GES激活了受胃扩张兴奋（GD-E）和抑制（GD-I）的神经元；它兴奋了48.4%（16/33）的GD-E神经元和60.4%（29/48）的GD-I神经元。2） 脉冲宽度增加的GES在兴奋GD反应性神经元方面效果最高，而刺激频率降低则导致激活程度降低。3） 用于治疗胃轻瘫的参数的GES引发的神经元反应与用于治疗肥胖症的参数的GES引发的反应相反。
GES激活PVN中与胃相关的神经元，GES的兴奋作用似乎与刺激强度有关。用于治疗胃轻瘫的GES和用于治疗肥胖症的GES似乎在PVN中引发不同的神经元反应。
